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Darunavir, Ritonavir and Etravirine
Darunavir, Ritonavir and Etravirine is a Antiretroviral combination (protease inhibitor + NNRTI) Small molecule drug developed by Imperial College London. It is currently FDA-approved for HIV-1 infection in treatment-experienced patients with resistance to other antiretrovirals. Also known as: Prezista, Norvir, Intelence.
This combination inhibits HIV protease and reverse transcriptase to block viral replication in HIV-infected patients.
This combination inhibits HIV protease and reverse transcriptase to block viral replication in HIV-infected patients. Used for HIV-1 infection in treatment-experienced patients with resistance to other antiretrovirals.
At a glance
| Generic name | Darunavir, Ritonavir and Etravirine |
|---|---|
| Also known as | Prezista, Norvir, Intelence |
| Sponsor | Imperial College London |
| Drug class | Antiretroviral combination (protease inhibitor + NNRTI) |
| Target | HIV protease, HIV reverse transcriptase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Darunavir and ritonavir are protease inhibitors that prevent HIV protease from cleaving viral polyproteins, while etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks reverse transcriptase activity. Together, they target multiple steps of the HIV replication cycle to suppress viral load.
Approved indications
- HIV-1 infection in treatment-experienced patients with resistance to other antiretrovirals
Common side effects
- Diarrhea
- Nausea
- Headache
- Rash
- Elevated liver enzymes
Key clinical trials
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- Trial to Evaluate the Interest of a Reductive Anti Retroviral Strategy Using Dual Therapy Inspite of Triple Therapy (PHASE3)
- Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
- Study Evaluating the Safety, in Terms of HBV Virological Control At 96 Weeks, of 2 Antiviral Treatment Relief Strategies, in Patients Co-infected with the HIV-1 and HBV Viruses (PHASE2)
- B-free Multistage Trial (PHASE4)
- Drug-drug Interaction (DDI) Study of GSK3640254 With Darunavir/Ritonavir (DRV/RTV) and Etravirine (ETR) (PHASE1)
- Optimizing Treatment for Treatment-Experienced, HIV-Infected People (PHASE3)
- CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Darunavir, Ritonavir and Etravirine CI brief — competitive landscape report
- Darunavir, Ritonavir and Etravirine updates RSS · CI watch RSS
- Imperial College London portfolio CI
Frequently asked questions about Darunavir, Ritonavir and Etravirine
What is Darunavir, Ritonavir and Etravirine?
How does Darunavir, Ritonavir and Etravirine work?
What is Darunavir, Ritonavir and Etravirine used for?
Who makes Darunavir, Ritonavir and Etravirine?
Is Darunavir, Ritonavir and Etravirine also known as anything else?
What drug class is Darunavir, Ritonavir and Etravirine in?
What development phase is Darunavir, Ritonavir and Etravirine in?
What are the side effects of Darunavir, Ritonavir and Etravirine?
What does Darunavir, Ritonavir and Etravirine target?
Related
- Drug class: All Antiretroviral combination (protease inhibitor + NNRTI) drugs
- Target: All drugs targeting HIV protease, HIV reverse transcriptase
- Manufacturer: Imperial College London — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for HIV-1 infection in treatment-experienced patients with resistance to other antiretrovirals
- Also known as: Prezista, Norvir, Intelence
- Compare: Darunavir, Ritonavir and Etravirine vs similar drugs
- Pricing: Darunavir, Ritonavir and Etravirine cost, discount & access