Last reviewed · How we verify

LPV/RTV pellets and AZT/3TC or ABC/3TC

Drugs for Neglected Diseases · Phase 3 active Small molecule

LPV/RTV pellets and AZT/3TC or ABC/3TC is a Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) Small molecule drug developed by Drugs for Neglected Diseases. It is currently in Phase 3 development for HIV-1 infection in pediatric patients (pellet formulation).

This combination therapy uses protease inhibitors (lopinavir/ritonavir) to block HIV protease, combined with nucleoside reverse transcriptase inhibitors (AZT/3TC or ABC/3TC) to inhibit viral replication at multiple steps.

This combination therapy uses protease inhibitors (lopinavir/ritonavir) to block HIV protease, combined with nucleoside reverse transcriptase inhibitors (AZT/3TC or ABC/3TC) to inhibit viral replication at multiple steps. Used for HIV-1 infection in pediatric patients (pellet formulation).

At a glance

Generic nameLPV/RTV pellets and AZT/3TC or ABC/3TC
SponsorDrugs for Neglected Diseases
Drug classAntiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors)
TargetHIV protease, HIV reverse transcriptase
ModalitySmall molecule
Therapeutic areaInfectious Disease / Virology
PhasePhase 3

Mechanism of action

Lopinavir/ritonavir (LPV/RTV) inhibits HIV protease, preventing the maturation of viral particles and reducing infectious virions. The nucleoside reverse transcriptase inhibitors (AZT/3TC or ABC/3TC) block reverse transcriptase, preventing conversion of viral RNA to DNA. Together, these agents provide synergistic suppression of HIV replication through complementary mechanisms. The pellet formulation is designed for pediatric administration.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about LPV/RTV pellets and AZT/3TC or ABC/3TC

What is LPV/RTV pellets and AZT/3TC or ABC/3TC?

LPV/RTV pellets and AZT/3TC or ABC/3TC is a Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) drug developed by Drugs for Neglected Diseases, indicated for HIV-1 infection in pediatric patients (pellet formulation).

How does LPV/RTV pellets and AZT/3TC or ABC/3TC work?

This combination therapy uses protease inhibitors (lopinavir/ritonavir) to block HIV protease, combined with nucleoside reverse transcriptase inhibitors (AZT/3TC or ABC/3TC) to inhibit viral replication at multiple steps.

What is LPV/RTV pellets and AZT/3TC or ABC/3TC used for?

LPV/RTV pellets and AZT/3TC or ABC/3TC is indicated for HIV-1 infection in pediatric patients (pellet formulation).

Who makes LPV/RTV pellets and AZT/3TC or ABC/3TC?

LPV/RTV pellets and AZT/3TC or ABC/3TC is developed by Drugs for Neglected Diseases (see full Drugs for Neglected Diseases pipeline at /company/drugs-for-neglected-diseases).

What drug class is LPV/RTV pellets and AZT/3TC or ABC/3TC in?

LPV/RTV pellets and AZT/3TC or ABC/3TC belongs to the Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) class. See all Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors) drugs at /class/antiretroviral-combination-therapy-protease-inhibitor-nucleoside-reverse-transcriptase-inhibitors.

What development phase is LPV/RTV pellets and AZT/3TC or ABC/3TC in?

LPV/RTV pellets and AZT/3TC or ABC/3TC is in Phase 3.

What are the side effects of LPV/RTV pellets and AZT/3TC or ABC/3TC?

Common side effects of LPV/RTV pellets and AZT/3TC or ABC/3TC include Diarrhea, Nausea, Lipid abnormalities, Hepatotoxicity, Pancreatitis, Peripheral neuropathy (AZT-related).

What does LPV/RTV pellets and AZT/3TC or ABC/3TC target?

LPV/RTV pellets and AZT/3TC or ABC/3TC targets HIV protease, HIV reverse transcriptase and is a Antiretroviral combination therapy (protease inhibitor + nucleoside reverse transcriptase inhibitors).

Related