Who are Initiation of CFTR Modulator's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Ivacaftor and Symdeko, LUM/IVA, Elexacaftor / Ivacaftor / Tezacaftor, Ivacaftor+lumacaftor, Ivacaftor/Ataluren, VNZ/TEZ/D-IVA.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Initiation of CFTR Modulator — Competitive Intelligence Brief

Initiation of CFTR Modulator (Initiation of CFTR Modulator) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: CFTR modulator. Area: Pulmonary/Genetic.

marketed CFTR modulator CFTR (cystic fibrosis transmembrane conductance regulator) Pulmonary/Genetic Small molecule Live · refreshed every 30 min

Target snapshot

Initiation of CFTR Modulator (Initiation of CFTR Modulator) — Children's Hospital Medical Center, Cincinnati. CFTR modulators restore function to the cystic fibrosis transmembrane conductance regulator (CFTR) protein, improving chloride ion transport across cell membranes.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Initiation of CFTR Modulator TARGET	Initiation of CFTR Modulator	Children's Hospital Medical Center, Cincinnati	marketed	CFTR modulator	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor and Symdeko	Ivacaftor and Symdeko	University of Alabama at Birmingham	marketed	CFTR modulator (potentiator and corrector combination)	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
LUM/IVA	LUM/IVA	Vertex Pharmaceuticals Incorporated	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Elexacaftor / Ivacaftor / Tezacaftor	Elexacaftor / Ivacaftor / Tezacaftor	Nottingham University Hospitals NHS Trust	marketed	CFTR modulator combination (correctors + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor+lumacaftor	Ivacaftor+lumacaftor	Assistance Publique - Hôpitaux de Paris	marketed	CFTR modulator combination (corrector + potentiator)	CFTR (cystic fibrosis transmembrane conductance regulator)
Ivacaftor/Ataluren	Ivacaftor/Ataluren	University of Alabama at Birmingham	marketed	CFTR modulator combination	CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
VNZ/TEZ/D-IVA	VNZ/TEZ/D-IVA	Vertex Pharmaceuticals Incorporated	phase 3	CFTR modulator	CFTR

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (CFTR modulator class)

Vertex Pharmaceuticals Incorporated · 5 drugs in this class
Chiesi Farmaceutici S.p.A. · 1 drug in this class
Children's Hospital Medical Center, Cincinnati · 1 drug in this class
Hospices Civils de Lyon · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Initiation of CFTR Modulator — Competitive Intelligence Brief. https://druglandscape.com/ci/initiation-of-cftr-modulator. Accessed 2026-05-16.

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