Inhaled sedation with sevoflurane — Competitive Intelligence Brief

Inhaled sedation with sevoflurane (Inhaled sedation with sevoflurane) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Volatile anesthetic. Area: Anesthesia/Sedation.

phase 3 Volatile anesthetic GABA-A receptor, NMDA glutamate receptor Anesthesia/Sedation Small molecule

Target snapshot

Inhaled sedation with sevoflurane (Inhaled sedation with sevoflurane) — University Hospital, Clermont-Ferrand. Sevoflurane is a volatile anesthetic that depresses central nervous system activity by enhancing inhibitory GABA signaling and inhibiting excitatory glutamate signaling, producing sedation and anesthesia.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Inhaled sedation with sevoflurane TARGET	Inhaled sedation with sevoflurane	University Hospital, Clermont-Ferrand	phase 3	Volatile anesthetic	GABA-A receptor, NMDA glutamate receptor
Sevoflurane or Propofol	Sevoflurane or Propofol	University Health Network, Toronto	marketed	General anesthetic	GABA-A receptor, NMDA glutamate receptor
Sevorane (sevoflurane, Abbott)	Sevorane (sevoflurane, Abbott)	Medical University of Gdansk	marketed	Volatile anesthetic	GABA-A receptor, NMDA glutamate receptor
Sevoflurane inhalant product	Sevoflurane inhalant product	Sunnybrook Health Sciences Centre	marketed	Volatile inhalational anesthetic	GABA-A receptor, NMDA glutamate receptor
General sevoflurane anaesthesia	General sevoflurane anaesthesia	KK Women's and Children's Hospital	phase 3	Volatile anesthetic agent	GABA-A receptor, NMDA glutamate receptor
Remifentanil and Desflurane	Remifentanil and Desflurane	The Cooper Health System	marketed	Opioid agonist and volatile anesthetic combination	Mu-opioid receptor (remifentanil); GABA receptors and ion channels (desflurane)
Sevoflurane, Isoflurane, Desflurane	Sevoflurane, Isoflurane, Desflurane	University Hospital, Basel, Switzerland	marketed	Volatile anesthetic	GABA-A receptor, NMDA receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Volatile anesthetic class)

1. Medical University of Gdansk · 2 drugs in this class
2. Assistance Publique - Hôpitaux de Paris · 1 drug in this class
3. Federal University of São Paulo · 1 drug in this class
4. King's College Hospital NHS Trust · 1 drug in this class
5. London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · 1 drug in this class
6. The Cleveland Clinic · 1 drug in this class
7. University Hospital, Basel, Switzerland · 1 drug in this class
8. Asan Medical Center · 1 drug in this class
9. University Hospital, Clermont-Ferrand · 1 drug in this class