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General sevoflurane anaesthesia
Sevoflurane is a volatile anesthetic that depresses central nervous system activity by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
Sevoflurane is a volatile anesthetic that depresses central nervous system activity by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling. Used for General anesthesia for surgical procedures, Maintenance of anesthesia in pediatric and adult patients.
At a glance
| Generic name | General sevoflurane anaesthesia |
|---|---|
| Also known as | Gas |
| Sponsor | KK Women's and Children's Hospital |
| Drug class | Volatile anesthetic agent |
| Target | GABA-A receptor, NMDA glutamate receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Sevoflurane is a halogenated ether that crosses the blood-brain barrier and modulates neuronal ion channels, primarily potentiating GABA-A receptors and blocking NMDA glutamate receptors. This dual action results in rapid loss of consciousness, amnesia, and analgesia. It is administered via inhalation and is rapidly eliminated through the lungs, allowing quick recovery.
Approved indications
- General anesthesia for surgical procedures
- Maintenance of anesthesia in pediatric and adult patients
Common side effects
- Postoperative nausea and vomiting
- Emergence delirium (pediatric)
- Airway irritation
- Hypotension
- Bradycardia
- Hepatotoxicity (rare)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy (NA)
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- Effects of Minimal and Metabolic Flow Sevoflurane Anesthesia in Gynecological Surgery Patients
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Comparison of Gastric Insufflation Volume Between LarySeal Pro and Ambu AuraGain Using Ultrasonography In Pediatric Patients Undergoing General Anesthesia With Controlled Ventilation. (NA)
- Effect of Different Concentrations of Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- General sevoflurane anaesthesia CI brief — competitive landscape report
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- KK Women's and Children's Hospital portfolio CI