Who are Hydrochlorothiazide (HCTZ)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): olmesartan medoxomil-hydrochlorothiazide, Benicar, Zestril, Capozide 25/15, TRIAMTERENE, Enduron.

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Last reviewed 2026-05-17 · How we verify

Hydrochlorothiazide (HCTZ) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hydrochlorothiazide (HCTZ) (Hydrochlorothiazide (HCTZ)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide diuretic. Area: Cardiovascular.

marketed Thiazide diuretic Sodium-chloride cotransporter (NCC) Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Hydrochlorothiazide (HCTZ) (Hydrochlorothiazide (HCTZ)) — Novartis. Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting water and electrolyte excretion to reduce blood volume and blood pressure.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Hydrochlorothiazide (HCTZ) TARGET	Hydrochlorothiazide (HCTZ)	Novartis	marketed	Thiazide diuretic	Sodium-chloride cotransporter (NCC)
olmesartan medoxomil-hydrochlorothiazide	OLMESARTAN	Cosette	marketed	Thiazide Diuretic [EPC]		2019-01-01
Benicar	OLMESARTAN MEDOXOMIL	Cosette	marketed	Thiazide Diuretic [EPC]	Type-1 angiotensin II receptor	2002-01-01
Zestril	lisinopril	Generic (originally Merck/AstraZeneca)	marketed	Thiazide Diuretic [EPC]	Angiotensin-converting enzyme, Angiotensin-converting enzyme	1987-12-29
Capozide 25/15	CAPTOPRIL	Aarxion Anda Hlding	marketed	Thiazide Diuretic [EPC]	Renin	1981-01-01
TRIAMTERENE	TRIAMTERENE		marketed	Thiazide Diuretic [EPC]		1964-01-01
Enduron	methylclothiazide		marketed	Thiazide Diuretic	Solute carrier family 12 member 3	1960-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2035-11-06 — Zestril · 9616096 · Method of Use · US
2035-11-06 — Zestril · 10039800 · Method of Use · US
2035-11-06 — Zestril · 10406199 · Method of Use · US
2035-11-06 — Zestril · 12433931 · Method of Use · US
2035-11-06 — Zestril · 10265370 · Formulation · US
2035-11-06 — Zestril · 9463183 · Formulation · US
2035-11-06 — Zestril · 11179434 · Formulation · US
2035-11-06 — Zestril · 9814751 · Formulation · US
2035-11-06 — Zestril · 10940177 · Formulation · US
2035-11-06 — Zestril · 11771733 · Formulation · US
2035-11-06 — Zestril · 12186360 · Formulation · US
2035-11-06 — Zestril · 12128083 · Formulation · US

Sponsor landscape (Thiazide diuretic class)

Cedars-Sinai Medical Center · 2 drugs in this class
National University of Ireland, Galway, Ireland · 1 drug in this class
Bristol-Myers Squibb · 1 drug in this class
Seiji Umemoto, M.D., Ph.D. · 1 drug in this class
Takeda · 1 drug in this class
University of Virginia · 1 drug in this class
Novartis · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Hydrochlorothiazide (HCTZ) — Competitive Intelligence Brief. https://druglandscape.com/ci/hydrochlorothiazide-hctz. Accessed 2026-05-17.

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