Higroton® Laboratório Novartis — Competitive Intelligence Brief

Higroton® Laboratório Novartis (Higroton® Laboratório Novartis) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

phase 3 Thiazide-like diuretic Sodium-chloride cotransporter (NCC) Cardiovascular Small molecule

Target snapshot

Higroton® Laboratório Novartis (Higroton® Laboratório Novartis) — Eurofarma Laboratorios S.A.. Higroton (chlorthalidone) is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting urinary excretion and reducing blood volume and blood pressure.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Higroton® Laboratório Novartis TARGET	Higroton® Laboratório Novartis	Eurofarma Laboratorios S.A.	phase 3	Thiazide-like diuretic	Sodium-chloride cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Metolazone Tablets	Metolazone Tablets	NHS Greater Glasgow and Clyde	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)
IV Furosemide and PO Metolazone	IV Furosemide and PO Metolazone	Rambam Health Care Campus	marketed	Loop diuretic and thiazide-like diuretic combination	Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-03-26 — Combipres · 9066936 · US
• 2030-02-04 — Combipres · 9169238 · US
• 2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

1. Eurofarma Laboratorios S.A. · 1 drug in this class
2. Farma de Colombia SA · 1 drug in this class
3. Hospices Civils de Lyon · 1 drug in this class
4. NHS Greater Glasgow and Clyde · 1 drug in this class
5. University of North Carolina, Chapel Hill · 1 drug in this class
6. University of Virginia · 1 drug in this class
7. VA Office of Research and Development · 1 drug in this class