Who are Estradiol (E2)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Vaginal estradiol tablets, estriol cream, Estradiol 0.01% Vag Cream, Estriol Cream 0.1%, estradiol valerat, Generic Estradiol Vaginal Cream USP, 0.01%.

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Last reviewed 2026-06-10 · How we verify

Estradiol (E2) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Estradiol (E2) (Estradiol (E2)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Estrogen receptor agonist. Area: Endocrinology.

phase 3 Estrogen receptor agonist Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ) Endocrinology Small molecule Live · refreshed every 30 min

Target snapshot

Estradiol (E2) (Estradiol (E2)) — Martin Blomberg Jensen. Estradiol binds to estrogen receptors (ERα and ERβ) in target tissues to modulate gene expression and produce estrogenic effects.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Estradiol (E2) TARGET	Estradiol (E2)	Martin Blomberg Jensen	phase 3	Estrogen receptor agonist	Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ)
Vaginal estradiol tablets	Vaginal estradiol tablets	Johns Hopkins University	marketed	Estrogen receptor agonist	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
estriol cream	estriol cream	Hatice Tukenmez Kurnaz	marketed	Estrogen receptor agonist	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Estradiol 0.01% Vag Cream	Estradiol 0.01% Vag Cream	TriHealth Inc.	marketed	Estrogen receptor agonist	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
Estriol Cream 0.1%	Estriol Cream 0.1%	Dr. August Wolff GmbH & Co. KG Arzneimittel	marketed	Estrogen receptor agonist	Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)
estradiol valerat	estradiol valerat	farzaneh hojjat	marketed	Estrogen receptor agonist	Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ)
Generic Estradiol Vaginal Cream USP, 0.01%	Generic Estradiol Vaginal Cream USP, 0.01%	Actavis Inc.	phase 3	Estrogen receptor agonist	Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Estrogen receptor agonist class)

Actavis Inc. · 1 drug in this class
Bayer · 1 drug in this class
Dr. August Wolff GmbH & Co. KG Arzneimittel · 1 drug in this class
Hatice Tukenmez Kurnaz · 1 drug in this class
Johns Hopkins University · 1 drug in this class
Martin Blomberg Jensen · 1 drug in this class
TriHealth Inc. · 1 drug in this class
farzaneh hojjat · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Estradiol (E2) — Competitive Intelligence Brief. https://druglandscape.com/ci/estradiol-e2. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing