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EFV plus ABC/3TC or RPV/TDF/FTC — Competitive Intelligence Brief
phase 3
Antiretroviral combination therapy (NNRTI + NRTIs)
HIV reverse transcriptase
Infectious Disease / Virology
Small molecule
Live · refreshed every 30 min
Target snapshot
EFV plus ABC/3TC or RPV/TDF/FTC (EFV plus ABC/3TC or RPV/TDF/FTC) — Juan A. Arnaiz. This is a combination antiretroviral regimen that inhibits HIV reverse transcriptase and integrase to suppress viral replication.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| EFV plus ABC/3TC or RPV/TDF/FTC TARGET | EFV plus ABC/3TC or RPV/TDF/FTC | Juan A. Arnaiz | phase 3 | Antiretroviral combination therapy (NNRTI + NRTIs) | HIV reverse transcriptase | |
| Sofosbuvir, Ribavirin, and Stribild | Sofosbuvir, Ribavirin, and Stribild | Saint Michael's Medical Center | marketed | Direct-acting antiviral (DAA) combination; antiretroviral combination | HCV NS5B RNA polymerase; HIV integrase; HIV reverse transcriptase | |
| Abacavir sulfate, Lamivudine and Zidovudine | Abacavir sulfate, Lamivudine and Zidovudine | National Institute of Allergy and Infectious Diseases (NIAID) | marketed | Nucleoside reverse transcriptase inhibitor (NRTI) combination | HIV reverse transcriptase | |
| AZT | AZT | Johns Hopkins Bloomberg School of Public Health | marketed | Nucleoside reverse transcriptase inhibitor (NRTI) | HIV reverse transcriptase | |
| "Raltegravir" and "Zidovudine" | "Raltegravir" and "Zidovudine" | Universidad Peruana Cayetano Heredia | marketed | Antiretroviral combination (integrase inhibitor + nucleoside reverse transcriptase inhibitor) | HIV integrase (raltegravir); HIV reverse transcriptase (zidovudine) | |
| Tenofovir/Emtricitabine | Tenofovir/Emtricitabine | Bristol-Myers Squibb | marketed | Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination | HIV reverse transcriptase | |
| TDF/3TC/EFV or DTG or NVP | TDF/3TC/EFV or DTG or NVP | MU-JHU CARE | marketed | Antiretroviral combination therapy (NRTI + NNRTI or INSTI) | HIV reverse transcriptase, HIV integrase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antiretroviral combination therapy (NNRTI + NRTIs) class)
- Institut de Recherche pour le Developpement · 1 drug in this class
- Juan A. Arnaiz · 1 drug in this class
- University of Cologne · 1 drug in this class
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Cite this brief
Drug Landscape (2026). EFV plus ABC/3TC or RPV/TDF/FTC — Competitive Intelligence Brief. https://druglandscape.com/ci/efv-plus-abc-3tc-or-rpv-tdf-ftc. Accessed 2026-05-16.
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