How many drugs treat toothache?

Drug Landscape tracks 5 marketed treatments for toothache (deduplicated by molecule). 0 Phase 3 candidates and 0 Phase 2 candidates are in the pipeline.

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Last reviewed 2026-06-10 · How we verify

toothache — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

toothache (disease) competitive landscape: 5 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

5 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating toothache, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Excedrin Extra Strength Pain Reliever	NSAID	Haleon Us Holdings	Nonsteroidal Anti-inflammatory Drug [EPC]	Cyclooxygenase	2004-01-01
Aleve	naproxen	Generic (originally Syntex)	NSAID	Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Prostaglandin G/H synthase 1	1976-01-01
Acetaminophen	Paracetamol	Polymedica	acetaminophen	Transient receptor potential cation channel subfamily V member 4	1968-01-01
Norgesic	acetylsalicylic acid	Endo	centrally acting muscle relaxant with anticholinergic properties	reticular formation (brain stem)	1950-01-01
MEDIQUE APAP EXTRA STRENGTH acetaminophen tablet, film coated	APAP	HF Acquisition Co LLC, DBA HealthFirst

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

Endo · 1 drug in toothache
Generic (originally Syntex) · 1 drug in toothache
HF Acquisition Co LLC, DBA HealthFirst · 1 drug in toothache
Haleon Us Holdings · 1 drug in toothache
Polymedica · 1 drug in toothache

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Every new regulatory action, PDUFA date, or trial completion in toothache:

Cite this brief

Drug Landscape (2026). toothache — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/toothache. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing