How many drugs treat Severe adrenal insufficiency?

Drug Landscape tracks 9 marketed treatments for Severe adrenal insufficiency (deduplicated by molecule). 0 Phase 3 candidates and 0 Phase 2 candidates are in the pipeline.

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Last reviewed 2026-06-10 · How we verify

Severe adrenal insufficiency — Treatment Landscape & Competitive Intelligence

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Severe adrenal insufficiency (disease) competitive landscape: 9 marketed treatments tracked, 0 Phase 3 candidates, 0 Phase 2 candidates. Recent regulatory actions and upcoming PDUFA dates across the entire treatment set.

9 marketed 0 Phase 3 0 Phase 2 Live · 30-min refresh

Marketed treatment landscape

Approved drugs treating Severe adrenal insufficiency, deduplicated by molecule. See the full disease page for line-of-therapy detail.

Drug	Generic	Sponsor	Class	Target	First approval
Decadron	dexamethasone	Generic (originally Merck)	Corticosteroid [EPC]	Annexin A1, Interleukin-4, Androgen receptor	1958-10-30
Medrol	methylprednisolone	Generic (originally Upjohn/Pfizer)	Glucocorticoid (corticosteroid)	Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor	1957-10-01
Prelone	prednisolone	Generic (originally Schering)	Glucocorticoid (corticosteroid)	Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1	1955-01-01
Solu-Cortef	hydrocortisone succinate	Pfizer	Corticosteroid	Glucocorticoid receptor	1955-01-01
Cortef	hydrocortisone	Generic (originally Merck/Upjohn)	Corticosteroid [EPC]	Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible	1952-01-01
Cortifoam	HYDROCORTISONE ACETATE	Pfizer	Corticosteroid	Corticosteroid-binding globulin	1951-01-01
Cortisol	Cortisol	University of Zurich		Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible
prednisolon	prednisolon	Hannover Medical School		Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1
Methylprednisolon	Methylprednisolon	Leiden University Medical Center		Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor

Phase 3 pipeline

No Phase 3 pipeline candidates tracked.

Phase 2 pipeline

No Phase 2 pipeline candidates tracked.

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this treatment set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this treatment set.

Sponsor landscape

· 4 drugs in Severe adrenal insufficiency
Pfizer · 2 drugs in Severe adrenal insufficiency
Generic (originally Merck/Upjohn) · 1 drug in Severe adrenal insufficiency
Generic (originally Schering) · 1 drug in Severe adrenal insufficiency
Generic (originally Upjohn/Pfizer) · 1 drug in Severe adrenal insufficiency
Hannover Medical School · 1 drug in Severe adrenal insufficiency
Leiden University Medical Center · 1 drug in Severe adrenal insufficiency
University of Zurich · 1 drug in Severe adrenal insufficiency
Generic (originally Merck) · 1 drug in Severe adrenal insufficiency

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Every new regulatory action, PDUFA date, or trial completion in Severe adrenal insufficiency:

Cite this brief

Drug Landscape (2026). Severe adrenal insufficiency — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/severe-adrenal-insufficiency. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing