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Fever — Treatment Landscape & Competitive Intelligence
10 marketed
0 Phase 3
0 Phase 2
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Marketed treatment landscape
| Drug | Generic | Sponsor | Class | Target | Line of therapy | First approval |
|---|---|---|---|---|---|---|
| Aleve | naproxen | Generic (originally Syntex) | NSAID | Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Prostaglandin G/H synthase 1 | 1976-01-01 | |
| Sudafed PE | phenylephrine | Generic (multiple manufacturers) | Alpha-1 adrenergic agonist (decongestant/vasopressor) | Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-1D adrenergic receptor | 1976-01-01 | |
| Immune Support | CORTISONE | Merck | Non-Standardized Plant Allergenic Extract [EPC] | 1974-01-01 | ||
| Lithobid | lithium carbonate | Generic (multiple manufacturers) | Mood stabilizer | Inositol-1(or 4)-monophosphatase 1, Glycogen synthase kinase-3 | 1970-04-06 | |
| Advil | ibuprofen | Generic (originally Boots Group) | Nonsteroidal Anti-inflammatory Drug [EPC] | Sodium-coupled monocarboxylate transporter 1, Acid-sensing ion channel 1, Aldo-keto reductase family 1 member C2 | 1969-01-15 | |
| Acetaminophen | Paracetamol | Polymedica | acetaminophen | Transient receptor potential cation channel subfamily V member 4 | 1968-01-01 | |
| Delsym | dextromethorphan | Generic (originally Roche) | Antitussive (non-opioid) | Taste receptor type 2 member 46, Solute carrier family 22 member 1, Cytochrome P450 2D6 | 1958-01-01 | |
| Mucinex | guaifenesin | Generic (multiple manufacturers) | Expectorant [EPC] | Vagal gastric reflex → increased respiratory secretions | 1952-01-01 | |
| Phenergan Vc W/ Codeine | PHENYLEPHRINE BITARTRATE | ANI Pharmaceuticals | Nonsteroidal Anti-inflammatory Drug [EPC] | Alpha-1B adrenergic receptor | 1952-01-01 | |
| Codeine | codeine phosphate | Generic (multiple manufacturers) | Opioid analgesic, Antitussive | Delta-type opioid receptor, Kappa-type opioid receptor, Mu-type opioid receptor | 1950-01-01 |
Phase 3 pipeline
Phase 2 pipeline
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Sponsor landscape
- Generic (multiple manufacturers) · 4 drugs in Fever
- · 4 drugs in Fever
- Generic (originally Boots Group) · 1 drug in Fever
- Generic (originally Roche) · 1 drug in Fever
- Generic (originally Syntex) · 1 drug in Fever
- HF Acquisition Co LLC, DBA HealthFirst · 1 drug in Fever
- Merck · 1 drug in Fever
- Pfizer · 1 drug in Fever
- Polymedica · 1 drug in Fever
- ANI Pharmaceuticals · 1 drug in Fever
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Cite this brief
Drug Landscape (2026). Fever — Treatment Landscape & Competitive Intelligence Brief. https://druglandscape.com/ci/disease/fever. Accessed 2026-06-10.
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing