Who are cross-linked hyaluronic acid's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): viscosupplementation 1+1+1, Hyaluronic acid (HA), Hylan GF-20 alone, Hyaluronic Acid Injection, vitagen plus hyruan, Hyalgan (sodium hyaluronate).

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Last reviewed 2026-05-18 · How we verify

cross-linked hyaluronic acid — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

cross-linked hyaluronic acid (cross-linked hyaluronic acid) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Viscosupplement. Area: Orthopedics / Rheumatology.

marketed Viscosupplement Orthopedics / Rheumatology Small molecule Live · refreshed every 30 min

Target snapshot

cross-linked hyaluronic acid (cross-linked hyaluronic acid) — Taipei Medical University. Cross-linked hyaluronic acid forms a viscoelastic gel that lubricates and cushions joints by mimicking natural synovial fluid.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
cross-linked hyaluronic acid TARGET	cross-linked hyaluronic acid	Taipei Medical University	marketed	Viscosupplement
viscosupplementation 1+1+1	viscosupplementation 1+1+1	University of Sao Paulo General Hospital	marketed	Hyaluronic acid derivative; viscosupplement	Hyaluronic acid receptor (CD44); joint synovial fluid
Hyaluronic acid (HA)	Hyaluronic acid (HA)	Chinese University of Hong Kong	marketed	Viscosupplement / Biological polymer
Hylan GF-20 alone	Hylan GF-20 alone	University of Sao Paulo General Hospital	marketed	Viscosupplement	Hyaluronic acid receptor (CD44)
Hyaluronic Acid Injection	Hyaluronic Acid Injection	Wroclaw Medical University	marketed	Viscosupplement
vitagen plus hyruan	vitagen plus hyruan	Taipei Medical University	marketed	Viscosupplement / Joint lubricant	Hyaluronic acid receptor (CD44); joint synovial fluid
Hyalgan (sodium hyaluronate)	Hyalgan (sodium hyaluronate)	Sanofi	marketed	Viscosupplement	Synovial fluid replacement (non-receptor mediated)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Viscosupplement class)

Istituto Ortopedico Rizzoli · 1 drug in this class
LG Life Sciences · 1 drug in this class
ProChon Biotech Ltd · 1 drug in this class
Sanofi · 1 drug in this class
Taipei Medical University · 1 drug in this class
University of Sao Paulo General Hospital · 1 drug in this class
Wroclaw Medical University · 1 drug in this class

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Cite this brief

Drug Landscape (2026). cross-linked hyaluronic acid — Competitive Intelligence Brief. https://druglandscape.com/ci/cross-linked-hyaluronic-acid. Accessed 2026-05-18.

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