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Hyaluronic acid (HA)
Hyaluronic acid is a naturally occurring polysaccharide that acts as a biological lubricant and structural component, reducing friction and providing viscoelastic support in joints and tissues.
Hyaluronic acid is a naturally occurring polysaccharide that acts as a biological lubricant and structural component, reducing friction and providing viscoelastic support in joints and tissues. Used for Osteoarthritis of the knee, Joint pain and stiffness associated with degenerative joint disease, Wound healing and tissue repair.
At a glance
| Generic name | Hyaluronic acid (HA) |
|---|---|
| Also known as | HA, 0.8% HA, 0.2% Hyaluronic acid |
| Sponsor | Chinese University of Hong Kong |
| Drug class | Viscosupplement / Biological polymer |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Hyaluronic acid (HA) is a high-molecular-weight glycosaminoglycan found naturally in connective tissues, synovial fluid, and the extracellular matrix. When administered intra-articularly or topically, it restores viscosity and elasticity to synovial fluid, reduces joint friction, and provides shock absorption. HA also exhibits anti-inflammatory properties by modulating immune responses and protecting cartilage from degradation.
Approved indications
- Osteoarthritis of the knee
- Joint pain and stiffness associated with degenerative joint disease
- Wound healing and tissue repair
Common side effects
- Injection site pain or swelling
- Transient joint effusion
- Local inflammation
Key clinical trials
- Clinical Investigation on Lips Treated With HA-filler (NA)
- Using Different Biomaterials to Preserve Bone After Tooth Extraction (NA)
- Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy (NA)
- Early vs Delayed Intravesical Blad-Care During BCG Therapy (NA)
- A Post-market-clinical Follow-up Investigation of Safety and Performance by Decoria® Voluma (NA)
- The Efficacy and Safety of a Single-Dose Hyaluronic Acid Injection in the Treatment of Knee Osteoarthritis
- Multi-centre, Open-label, First-in-man Study With Mucopad HA (NA)
- Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hyaluronic acid (HA) CI brief — competitive landscape report
- Hyaluronic acid (HA) updates RSS · CI watch RSS
- Chinese University of Hong Kong portfolio CI