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Clomifene Citrate — Competitive Intelligence Brief

Clomifene Citrate (Clomifene Citrate) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Selective estrogen receptor modulator (SERM). Area: Reproductive/Fertility.

marketed Selective estrogen receptor modulator (SERM) Estrogen receptor (ER-α and ER-β) Reproductive/Fertility Small molecule Live · refreshed every 30 min

Target snapshot

Clomifene Citrate (Clomifene Citrate) — Fundació Privada Eugin. Clomifene citrate is a selective estrogen receptor modulator that blocks negative feedback of estrogen on the hypothalamic-pituitary-ovarian axis, thereby increasing gonadotropin secretion to stimulate ovulation.

Comparator set (6 drugs)

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DrugGenericSponsorPhaseClassTargetApproval / PDUFA
Clomifene Citrate TARGET Clomifene Citrate Fundació Privada Eugin marketed Selective estrogen receptor modulator (SERM) Estrogen receptor (ER-α and ER-β)
Tamoxifen (open label) Tamoxifen (open label) Oregon Health and Science University marketed Selective estrogen receptor modulator (SERM) Estrogen receptor alpha (ERα)
tamoxifen citrate (Tamoxifen) tamoxifen citrate (Tamoxifen) H. Lee Moffitt Cancer Center and Research Institute marketed Selective estrogen receptor modulator (SERM) Estrogen receptor alpha (ERα)
Metformin plus clomiphene citrate Metformin plus clomiphene citrate University Magna Graecia marketed Combination therapy: biguanide + selective estrogen receptor modulator (SERM) Insulin signaling pathway (metformin); estrogen receptor (clomiphene citrate)
High Dose Clomiphencitrat High Dose Clomiphencitrat University Hospital, Basel, Switzerland marketed Selective estrogen receptor modulator (SERM) Estrogen receptor (ER-α and ER-β)
raloxifene HCI and alendronate Na raloxifene HCI and alendronate Na Eli Lilly and Company marketed Selective estrogen receptor modulator (SERM) + bisphosphonate combination Estrogen receptor (raloxifene); osteoclast farnesyl pyrophosphate synthase (alendronate)
Metformin + Clomiphene Metformin + Clomiphene University of Auckland, New Zealand marketed Combination therapy: biguanide + selective estrogen receptor modulator (SERM) Metformin: AMP-activated protein kinase (AMPK); Clomiphene: estrogen receptor (ER)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Selective estrogen receptor modulator (SERM) class)

  1. University Hospital, Basel, Switzerland · 2 drugs in this class
  2. AstraZeneca · 2 drugs in this class
  3. Estetra · 1 drug in this class
  4. Fundació Privada Eugin · 1 drug in this class
  5. H. Lee Moffitt Cancer Center and Research Institute · 1 drug in this class
  6. National Taiwan University Hospital · 1 drug in this class
  7. Oregon Health and Science University · 1 drug in this class
  8. Samsung Medical Center · 1 drug in this class
  9. Shandong Suncadia Medicine Co., Ltd. · 1 drug in this class
  10. Sheba Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Clomifene Citrate — Competitive Intelligence Brief. https://druglandscape.com/ci/clomifene-citrate. Accessed 2026-05-14.

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