Last reviewed · How we verify
Clomifene Citrate
Clomifene citrate is a selective estrogen receptor modulator that blocks negative feedback of estrogen on the hypothalamic-pituitary-ovarian axis, thereby increasing gonadotropin secretion to stimulate ovulation.
Clomifene citrate is a selective estrogen receptor modulator that blocks negative feedback of estrogen on the hypothalamic-pituitary-ovarian axis, thereby increasing gonadotropin secretion to stimulate ovulation. Used for Anovulation and oligoovulation in women seeking pregnancy, Male infertility due to low testosterone or oligospermia.
At a glance
| Generic name | Clomifene Citrate |
|---|---|
| Also known as | clomid |
| Sponsor | Fundació Privada Eugin |
| Drug class | Selective estrogen receptor modulator (SERM) |
| Target | Estrogen receptor (ER-α and ER-β) |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
By competitively binding to estrogen receptors in the hypothalamus and pituitary, clomifene prevents the normal inhibitory effects of endogenous estrogen on GnRH and gonadotropin release. This results in increased FSH and LH secretion, which stimulates follicular development and ovulation in women with anovulation or oligoovulation. In men, it increases testosterone production by stimulating testicular function.
Approved indications
- Anovulation and oligoovulation in women seeking pregnancy
- Male infertility due to low testosterone or oligospermia
Common side effects
- Hot flushes
- Ovarian hyperstimulation syndrome (OHSS)
- Abdominal discomfort or bloating
- Nausea
- Visual disturbances
- Headache
- Mood changes
Key clinical trials
- FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea (PHASE3)
- INTEnsity of ovariaN Stimulation and Embryo Quality (PHASE4)
- Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial (PHASE2)
- Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate (PHASE4)
- The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface.
- The Effect of Therapy Combination in PCOS With Dlbs 3233 (EARLY_PHASE1)
- Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction (NA)
- Ovarian Hyperstimulation and Fibrin Clot Properties. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Clomifene Citrate CI brief — competitive landscape report
- Clomifene Citrate updates RSS · CI watch RSS
- Fundació Privada Eugin portfolio CI