CHLORTHALIDONE — Competitive Intelligence Brief

CHLORTHALIDONE (CHLORTHALIDONE) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like Diuretic [EPC]. Area: Metabolic.

marketed Thiazide-like Diuretic [EPC] Na+/Cl− cotransporter Metabolic Small molecule

Target snapshot

CHLORTHALIDONE (CHLORTHALIDONE).

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
CHLORTHALIDONE TARGET	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
IV Furosemide and PO Metolazone	IV Furosemide and PO Metolazone	Rambam Health Care Campus	marketed	Loop diuretic and thiazide-like diuretic combination	Na-K-2Cl cotransporter (NKCC2) and Na-Cl cotransporter (NCC)
Metolazone concurrently with furosemide	Metolazone concurrently with furosemide	University of Maryland, Baltimore	marketed	Thiazide-like diuretic and loop diuretic combination	Sodium-chloride cotransporter (NCC) and sodium-potassium-chloride cotransporter (NKCC2)
Metolazone Oral Tablet	Metolazone Oral Tablet	University of Virginia	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-03-26 — Combipres · 9066936 · US
• 2030-02-04 — Combipres · 9169238 · US
• 2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like Diuretic [EPC] class)

1. · 2 drugs in this class
2. I3 Pharms · 1 drug in this class