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brimonidine topical gel 0.33% & SOC — Competitive Intelligence Brief

brimonidine topical gel 0.33% & SOC (brimonidine topical gel 0.33% & SOC) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Alpha-2 adrenergic agonist. Area: Dermatology.

marketed Alpha-2 adrenergic agonist Alpha-2 adrenergic receptor Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

brimonidine topical gel 0.33% & SOC (brimonidine topical gel 0.33% & SOC) — Wake Forest University Health Sciences. Brimonidine is an alpha-2 adrenergic agonist that constricts blood vessels and reduces redness when applied topically to the skin.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

DrugGenericSponsorPhaseClassTargetApproval / PDUFA
brimonidine topical gel 0.33% & SOC TARGET brimonidine topical gel 0.33% & SOC Wake Forest University Health Sciences marketed Alpha-2 adrenergic agonist Alpha-2 adrenergic receptor
Pregabalin and dexmedetomidine Pregabalin and dexmedetomidine Wonkwang University Hospital marketed Combination analgesic/sedative (gabapentinoid + alpha-2 agonist) Alpha-2-delta calcium channel subunit (pregabalin); alpha-2 adrenergic receptor (dexmedetomidine)
oxymetazoline-fluticasone propionate oxymetazoline-fluticasone propionate Brian J Lipworth marketed Nasal decongestant/corticosteroid combination Alpha-2 adrenergic receptor; glucocorticoid receptor
Dexmedetomidine (DEX) Dexmedetomidine (DEX) Ain Shams University marketed Alpha-2 adrenergic receptor agonist Alpha-2 adrenergic receptor
Escitalopram+Mirtazapine Escitalopram+Mirtazapine Ministry of Health & Welfare, Korea marketed Antidepressant combination (SSRI + NaSSA) Serotonin transporter (SERT), norepinephrine transporter (NET), alpha-2 adrenergic receptors, histamine H1 receptors
Group D : Dexmedetomidine + propofol group Group D : Dexmedetomidine + propofol group Seoul National University Hospital marketed Sedative-hypnotic combination (alpha-2 agonist + GABA-A agonist) Alpha-2 adrenergic receptor (dexmedetomidine); GABA-A receptor (propofol)
Catapresan TTS 2 Catapresan TTS 2 Heart Care Foundation marketed Central alpha-2 adrenergic agonist Alpha-2 adrenergic receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Alpha-2 adrenergic agonist class)

  1. USWM, LLC (dba US WorldMeds) · 2 drugs in this class
  2. China International Neuroscience Institution · 1 drug in this class
  3. Icahn School of Medicine at Mount Sinai · 1 drug in this class
  4. Eye Therapies, LLC · 1 drug in this class
  5. Galderma R&D · 1 drug in this class
  6. Guangzhou Women and Children's Medical Center · 1 drug in this class
  7. Derm Research, PLLC · 1 drug in this class
  8. Irmandade da Santa Casa de Misericordia de Sao Paulo · 1 drug in this class
  9. KK Women's and Children's Hospital · 1 drug in this class
  10. American University of Beirut Medical Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). brimonidine topical gel 0.33% & SOC — Competitive Intelligence Brief. https://druglandscape.com/ci/brimonidine-topical-gel-0-33-soc. Accessed 2026-05-18.

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