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Group D : Dexmedetomidine + propofol group
Dexmedetomidine and propofol are combined to provide sedation and anesthesia through alpha-2 adrenergic receptor agonism and GABA-A receptor potentiation, respectively.
Dexmedetomidine and propofol are combined to provide sedation and anesthesia through alpha-2 adrenergic receptor agonism and GABA-A receptor potentiation, respectively. Used for Sedation during anesthesia and mechanical ventilation in intensive care settings, Procedural sedation.
At a glance
| Generic name | Group D : Dexmedetomidine + propofol group |
|---|---|
| Sponsor | Seoul National University Hospital |
| Drug class | Sedative-hypnotic combination (alpha-2 agonist + GABA-A agonist) |
| Target | Alpha-2 adrenergic receptor (dexmedetomidine); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology / Critical Care |
| Phase | FDA-approved |
Mechanism of action
Dexmedetomidine is a selective alpha-2 adrenergic agonist that produces sedation, analgesia, and anxiolysis while maintaining airway reflexes. Propofol is a GABA-A receptor positive allosteric modulator that induces rapid sedation and hypnosis. The combination is used clinically to achieve balanced sedation-anesthesia with potentially reduced dosing requirements and improved safety profiles compared to either agent alone.
Approved indications
- Sedation during anesthesia and mechanical ventilation in intensive care settings
- Procedural sedation
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Injection site pain
Key clinical trials
- Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy
- Cognitive Function in Geriatric Colonoscopy Patients
- Procedural Sedation in Renal Sympathetic Denervation
- Dexmedetomidine vs Propofol in High-Risk ERCP Patients (NA)
- Prevention of Emergence Agitation in Rhinoplasty With Subanesthetic Propofol and Single-Dose Dexmedetomidine: A Prospective Double-Blind Clinical Study (NA)
- Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD (NA)
- Cognitive Functions After TIVA With Dexmedetomidine (PHASE4)
- The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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