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NCT07166614
Dexmedetomidine vs Propofol in High-Risk ERCP Patients
NA trial testing dexmedetomidin in Respiratory Depression in 2 participants. Currently enrolling.
30 December 2025
Quick facts
| Lead sponsor | Sisli Hamidiye Etfal Training and Research Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 2 |
| Start date | 3 September 2025 |
| Primary completion | 30 December 2025 |
| Estimated completion | 15 January 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- dexmedetomidin — full drug profile →
- Propofol (Propofol) — full drug profile →
Conditions studied
- Respiratory Depression — all drugs for Respiratory Depression →
- Hypoxemia — all drugs for Hypoxemia →
- Hypotension Drug-Induced — all drugs for Hypotension Drug-Induced →
- Bradycardia — all drugs for Bradycardia →
Sponsor
Sisli Hamidiye Etfal Training and Research Hospital
Who can join
18 and older, any sex, with Respiratory Depression or Hypoxemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
ERCP requires deep sedation due to pain and discomfort, but propofol-commonly used with opioids-often causes respiratory and cardiovascular complications, especially in elderly or high-risk patients. Dexmedetomidine offers sedation without respiratory depression but may lower blood pressure and heart rate. Current monitoring often relies only on SpO₂, while capnography and the Integrated Pulmonary Index (IPI) provide earlier detection of respiratory events but are underused in ERCP studies. This study compares dexmedetomidine and propofol in high-risk ERCP patients, focusing on respiratory and hemodynamic effects, propofol consumption, recovery, and discharge times. The hypothesis is that dexmedetomidine will cause fewer adverse respiratory and hemodynamic effects.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07166614
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Currently open trials in the same condition.
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07166614 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sisli Hamidiye Etfal Training and Research Hospital
- Last refreshed: 10 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07166614.
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