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Arsenic Trioxide Injectable Solution — Competitive Intelligence Brief
phase 2
Arsenic compound; differentiation agent and apoptosis inducer
PML-RARA fusion protein; mitochondrial apoptotic pathway
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Arsenic Trioxide Injectable Solution (Arsenic Trioxide Injectable Solution) — Medsenic. Arsenic trioxide induces differentiation and apoptosis in leukemic cells, particularly in acute promyelocytic leukemia (APL), through multiple pathways including PML-RARA protein degradation and reactive oxygen species generation.
Comparator set (3 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Arsenic Trioxide Injectable Solution TARGET | Arsenic Trioxide Injectable Solution | Medsenic | phase 2 | Arsenic compound; differentiation agent and apoptosis inducer | PML-RARA fusion protein; mitochondrial apoptotic pathway | |
| ATO | ATO | South China Children's Leukemia Group | marketed | Arsenic compound; differentiation agent | PML-RARA fusion protein; mitochondrial apoptotic pathways | |
| IV Arsenic Trioxide | IV Arsenic Trioxide | SDK Therapeutics, Inc. | phase 3 | Arsenic compound; differentiation agent and apoptosis inducer | PML-RARA fusion protein; mitochondrial apoptotic pathway | |
| Ibrutinib combined with As2O3 | Ibrutinib combined with As2O3 | Peking University People's Hospital | phase 3 | BTK inhibitor combined with arsenic compound | BTK (Bruton's tyrosine kinase); As2O3 has multiple targets including PML-RARA fusion protein and mitochondrial pathways |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Arsenic compound; differentiation agent and apoptosis inducer class)
- Medsenic · 1 drug in this class
- SDK Therapeutics, Inc. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Arsenic Trioxide Injectable Solution — Competitive Intelligence Brief. https://druglandscape.com/ci/arsenic-trioxide-injectable-solution. Accessed 2026-05-15.
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