Who are AJG555's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trulance, Linzess, Linaclotide 72 micrograms, XOI.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

AJG555 — Competitive Intelligence Brief

AJG555 (AJG555) competitive landscape: 4 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Guanylate cyclase-C agonist. Area: Gastroenterology.

phase 3 Guanylate cyclase-C agonist GC-C (guanylate cyclase-C) Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

AJG555 (AJG555) — EA Pharma Co., Ltd.. AJG555 is a guanylate cyclase-C (GC-C) agonist that increases intracellular cGMP to promote fluid secretion and accelerate intestinal transit.

Comparator set (4 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
AJG555 TARGET	AJG555	EA Pharma Co., Ltd.	phase 3	Guanylate cyclase-C agonist	GC-C (guanylate cyclase-C)
Trulance	PLECANATIDE	Salix	marketed	Guanylate Cyclase-C Agonist [EPC]	Tumor necrosis factor	2017-01-01
Linzess	LINACLOTIDE	AbbVie	marketed	Guanylate Cyclase-C Agonist [EPC]	Heat-stable enterotoxin receptor	2012-01-01
Linaclotide 72 micrograms	Linaclotide 72 micrograms	Md Mehedi Shahriar	marketed	Guanylate cyclase-C agonist	GC-C (guanylate cyclase-C receptor)
XOI	XOI	Ironwood Pharmaceuticals, Inc.	marketed	Guanylate cyclase-C agonist	GC-C (guanylate cyclase-C)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Guanylate cyclase-C agonist class)

EA Pharma Co., Ltd. · 1 drug in this class
Ironwood Pharmaceuticals, Inc. · 1 drug in this class
Md Mehedi Shahriar · 1 drug in this class

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Cite this brief

Drug Landscape (2026). AJG555 — Competitive Intelligence Brief. https://druglandscape.com/ci/ajg555. Accessed 2026-05-13.

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