Addition of oral Metolazone — Competitive Intelligence Brief

Addition of oral Metolazone (Addition of oral Metolazone) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

marketed Thiazide-like diuretic Sodium-chloride cotransporter (NCC) Cardiovascular Small molecule

Target snapshot

Addition of oral Metolazone (Addition of oral Metolazone) — University of North Carolina, Chapel Hill. Metolazone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting urinary excretion of water and electrolytes.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Addition of oral Metolazone TARGET	Addition of oral Metolazone	University of North Carolina, Chapel Hill	marketed	Thiazide-like diuretic	Sodium-chloride cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
Metolazone Oral Tablet	Metolazone Oral Tablet	University of Virginia	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)
Chlorthalidone with potassium chloride	Chlorthalidone with potassium chloride	Brigham and Women's Hospital	marketed	Thiazide-like diuretic with potassium supplement	Sodium-chloride cotransporter (NCC)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-03-26 — Combipres · 9066936 · US
• 2030-02-04 — Combipres · 9169238 · US
• 2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

1. Eurofarma Laboratorios S.A. · 1 drug in this class
2. Farma de Colombia SA · 1 drug in this class
3. Hospices Civils de Lyon · 1 drug in this class
4. NHS Greater Glasgow and Clyde · 1 drug in this class
5. University of North Carolina, Chapel Hill · 1 drug in this class
6. University of Virginia · 1 drug in this class
7. VA Office of Research and Development · 1 drug in this class