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NCT07532317
A Prospective, Multinational, Multicentre, Open-label, Randomized Trial to Evaluatesafety and Effectiveness of Meril's Myval Transcatheter Heart Valve (THV) Series Compared toGuideline-Directed Medical Therapy (GDMT) in Participants With Moderate Aortic Stenosis.
NA trial testing Transcatheter aortic valve replacement in Moderate Aortic Valve Stenosis in 778 participants. Not yet recruiting.
12 May 2028
Quick facts
| Lead sponsor | Meril Life Sciences Pvt. Ltd. |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 778 |
| Start date | 17 May 2026 |
| Primary completion | 12 May 2028 |
| Estimated completion | 12 May 2038 |
| Sites | 62 locations across Italy, Finland, Denmark, New Zealand, Netherlands, Sweden, Estonia, France |
Drugs / interventions tested
- Transcatheter aortic valve replacement
Conditions studied
- Moderate Aortic Valve Stenosis — all drugs for Moderate Aortic Valve Stenosis →
Sponsor
Meril Life Sciences Pvt. Ltd.
Who can join
65 and older, any sex, with Moderate Aortic Valve Stenosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of this trial is to evaluate the safety and effectiveness of Meril's Myval THV series in comparison to Guideline-Directed Medical Therapy in participants with moderate aortic stenosis. The trial includes a total of 778 participants (389:389) from approximately 50 investigator sites globally.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07532317
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Transcatheter aortic valve replacement
Trials testing the same drug.
- NCT06924151 — Isolated Surgical Aortic Valve Replacement in Low Risk AS Patients · NA · recruiting
- NCT06743568 — Efficacy of Self-expandable and Balloon-expandable Valves in Patients With Ascending Aortic Dilation · NA · recruiting
- NCT06589063 — Transcatheter Aortic Valve Replacement in Severe Low Flow, Low Gradient Aortic Stenosis · recruiting
- NCT06257043 — Safety and Efficacy of Post-marketing Transcatheter Aortic Valves in "Real World" Chinese Patients · recruiting
- NCT06136429 — A Prospective, Multicenter, Single-arm Study to Evaluate a Transcatheter Aortic Valve System Safety and Efficacy for the · NA · recruiting
Other recruiting trials for Moderate Aortic Valve Stenosis
Currently open trials in the same condition.
- NCT07001800 — Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study · Phase 2, PHASE3 · recruiting
- NCT06168123 — Future Optimal Research and Care Evaluation - Aortic Stenosis · recruiting
Other Meril Life Sciences Pvt. Ltd. trials
Trials by the same sponsor.
- NCT05417893 — Non-inferiority Clinical Trial to Compare the Safety and Performance of MeRes100 Sirolimus-eluting BioResorbable Vascula · NA · withdrawn
- NCT04033588 — Freedom® Total Knee System for Treatment of Osteoarthritis, Rheumatoid Arthritis or Post-traumatic Arthritis · NA · not yet recruiting
- NCT04275726 — LANDMARK Trial: a Randomised Controlled Trial of Myval THV · NA · recruiting
- NCT04703699 — Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis. · recruiting
- NCT03454724 — Study of MeRes100 in the Treatment of Patient With Coronary Artery Disease. · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07532317 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Meril Life Sciences Pvt. Ltd.
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07532317.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing