Last reviewed · How we verify
NCT06589063: LOW-TAVR
Transcatheter Aortic Valve Replacement in Severe Low Flow, Low Gradient Aortic Stenosis
trial testing Transcatheter aortic valve replacement in Low Flow, Low Gradient Aortic Stenosis in 1,350 participants. Currently enrolling.
1 September 2025
Quick facts
| Lead sponsor | University of Salerno |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,350 |
| Start date | 1 March 2024 |
| Primary completion | 1 September 2025 |
| Estimated completion | 31 December 2037 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Transcatheter aortic valve replacement
Conditions studied
- Low Flow, Low Gradient Aortic Stenosis — all drugs for Low Flow, Low Gradient Aortic Stenosis →
Sponsor
University of Salerno
Who can join
18 and older, any sex, with Low Flow, Low Gradient Aortic Stenosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
LOW-TAVR is a real-world, retrospective and prospective, multicenter Italian registry aimed at evaluating the characteristics and clinical outcomes of patients with severe low flow, low gradient aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) and, in particular: * risk factors * gender differences * comorbidities * pharmacological treatment * TAVR procedural characteristics * periprocedural and in-hospital complications * clinical outcome at 30-day, 1-year, 2-year and 5-year follow-up
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Balloon-Expandable Versus Self-Expanding Prostheses for Transcatheter Treatment of Patients With Low-Flow, Low-Gradient Aortic Stenosis.
Ferruzzi GJ, Bellino M, Silverio A, Saia F, et al · · 2026 · PMID 42132173 · DOI 10.1161/jaha.125.046441
Verify or expand the search:
- PubMed search for NCT06589063
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Salerno trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06589063 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Salerno
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06589063.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing