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NCT07528157
Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression
NA trial testing Personalized iTBS in Major Depressive Disorder in 80 participants. Not yet recruiting.
31 December 2027
Quick facts
| Lead sponsor | Stanford University |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 80 |
| Start date | 1 June 2026 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Personalized iTBS
- Non-Personalized iTBS
- Sham iTBS
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Treatment Resistant Depression — all drugs for Treatment Resistant Depression →
Sponsor
Stanford University
Who can join
Adults 18 to 65, any sex, with Major Depressive Disorder or Treatment Resistant Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study tests whether a brain stimulation treatment for depression called intermittent theta burst stimulation (iTBS) can be improved by tailoring it to each individual. A type of brain signal measured with electroencephalography (EEG) after a single pulse of brain stimulation, called an early local TMS-evoked potential (EL-TEP), is used to identify which stimulation settings work best for each participant. The investigators will compare individualized (personalized) iTBS settings to standard (non-personalized) settings and to inactive (sham) stimulation. Participants are adults with treatment-resistant depression.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07528157
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Other Stanford University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07528157 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Stanford University
- Last refreshed: 14 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07528157.