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NCT07517068
The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude
EARLY_PHASE1 trial testing ACETAZOLAMIDE oral capsule in Hypoxemia in 19 participants. Participants enrolled and being followed up; not accepting new ones.
15 June 2026
Quick facts
| Lead sponsor | University of California, Riverside |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 19 |
| Start date | 17 September 2025 |
| Primary completion | 15 June 2026 |
| Estimated completion | 15 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- ACETAZOLAMIDE oral capsule — full drug profile →
- Placebo Arm
Conditions studied
- Hypoxemia — all drugs for Hypoxemia →
- Acute Mountain Sickness (AMS) — all drugs for Acute Mountain Sickness (AMS) →
- Inflammation — all drugs for Inflammation →
- Immune Response — all drugs for Immune Response →
Sponsor
University of California, Riverside
Who can join
Adults 18 to 65, any sex, with Hypoxemia or Acute Mountain Sickness (AMS). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood cells that code for proteins that signal cell damage (damage associated molecular patterns (DAMPs)), cell receptors involved in innate immune responses, as well as increases in monocyte and neutrophil cells which promote inflammation. This study will investigate the potential mechanisms underlying these effects using the drug Acetazolamide, a carbonic anhydrase inhibitor which is known to reduce symptoms of Acute Mountain Sickness.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07517068
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of ACETAZOLAMIDE oral capsule
Trials testing the same drug.
- NCT03540914 — Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude. · Phase 4 · unknown
- NCT03537924 — Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude · Phase 4 · unknown
- NCT03539367 — Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude · Phase 4 · unknown
- NCT03540901 — Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude · Phase 4 · completed
- NCT03536507 — Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude · Phase 4 · completed
Other recruiting trials for Hypoxemia
Currently open trials in the same condition.
- NCT07451977 — Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia · NA · recruiting
- NCT07234188 — POM vs HFNC for Hypoxemia Prevention in Children · NA · recruiting
- NCT07175155 — Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbi · NA · recruiting
- NCT07037836 — Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia · Phase 2 · recruiting
- NCT07166614 — Dexmedetomidine vs Propofol in High-Risk ERCP Patients · NA · recruiting
Other University of California, Riverside trials
Trials by the same sponsor.
- NCT06122688 — By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Care · NA · not yet recruiting
- NCT07585630 — RCT of A1Cantus vs. Placebo · Phase 2 · not yet recruiting
- NCT07387146 — Community Health Worker Navigation to Support Mental Health · NA · not yet recruiting
- NCT06456372 — Digital Health Intervention for Children With ADHD · NA · recruiting
- NCT06530953 — Comparing Two Linkage-to-Care Models for Latinx Immigrant Patients : A Pilot Comparative Clinical Effectiveness Trial · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07517068 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, Riverside
- Last refreshed: 8 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07517068.
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