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NCT07512297: ESWL-PAIN
Pain Control During ESWL Using Non-Opioid Analgesics
Phase 4 trial testing Ibuprofen (Brufen®) in Urolithiasis in 160 participants. Not yet recruiting.
1 December 2026
Quick facts
| Lead sponsor | University of Gaziantep |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 160 |
| Start date | 1 April 2026 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 March 2027 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Ibuprofen (Brufen®) — full drug profile →
- Paracetamol (drug) — full drug profile →
- Tenoxicam — full drug profile →
- Placebo
Conditions studied
- Urolithiasis — all drugs for Urolithiasis →
- Kidney Stones — all drugs for Kidney Stones →
- Ureteral Stones — all drugs for Ureteral Stones →
Sponsor
University of Gaziantep
Who can join
Adults 18 to 75, any sex, with Urolithiasis or Kidney Stones. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This prospective randomized controlled trial aims to compare the analgesic efficacy of three non-opioid analgesics (ibuprofen, paracetamol, and tenoxicam) during extracorporeal shock wave lithotripsy (ESWL). All patients undergoing ESWL will be randomly assigned into four groups including a placebo group. Pain intensity will be assessed using the Visual Analog Scale (VAS) at the 5th, 10th, 15th, and 20th minutes during the procedure. In addition to comparing analgesic efficacy, the study will evaluate patient-related and stone-related factors affecting pain perception, including body mass index, subcutaneous fat thickness, and stone density measured by Hounsfield Units. The study also aims to assess the relationship between analgesic efficacy, energy levels applied during ESWL, and treatment outcomes such as stone-free rates. The findings may contribute to optimizing individualized pain management strategies and improving treatment efficiency in ESWL procedures.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07512297
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Related trials
Other trials of Ibuprofen (Brufen®)
Trials testing the same drug.
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Other University of Gaziantep trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07512297 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Gaziantep
- Last refreshed: 9 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07512297.
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