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NCT06989320
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
NA trial testing Low-oxalate diet and glycolate dosing in Kidney Stones in 80 participants. Currently enrolling.
31 December 2030
Quick facts
| Lead sponsor | University of Alabama at Birmingham |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 80 |
| Start date | 27 May 2025 |
| Primary completion | 31 December 2030 |
| Estimated completion | 31 December 2031 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Low-oxalate diet and glycolate dosing
- Oral glycolate dosing
- Oral 13C- ascorbic acid dosing
Conditions studied
- Kidney Stones — all drugs for Kidney Stones →
- Kidney Calculi — all drugs for Kidney Calculi →
- Urolithiasis — all drugs for Urolithiasis →
- Urolithiasis, Calcium Oxalate — all drugs for Urolithiasis, Calcium Oxalate →
Sponsor
University of Alabama at Birmingham
Who can join
Adults 18 to 80, any sex, with Kidney Stones or Kidney Calculi. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will ingest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine, blood, stool during the dietary and oral dosing portions of the study and also collect breath sample during the oral glycolate test
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06989320
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Kidney Stones
Currently open trials in the same condition.
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- NCT07225764 — CaOx Stone Prevention · Phase 4 · recruiting
- NCT07159035 — Flexible Ureteroscopy With a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithot · NA · recruiting
Other University of Alabama at Birmingham trials
Trials by the same sponsor.
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- NCT06320951 — VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine · Phase 2 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06989320 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alabama at Birmingham
- Last refreshed: 31 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06989320.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing