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NCT07507071: pCLE
Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions
trial testing Probe-based Confocal Laser Endomicroscopy in Early Gastric Cancer in 169 participants. Not yet recruiting.
10 April 2026
Quick facts
| Lead sponsor | Changhai Hospital |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 169 |
| Start date | 30 March 2026 |
| Primary completion | 10 April 2026 |
| Estimated completion | 15 April 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Probe-based Confocal Laser Endomicroscopy
- Pathological biopsy
Conditions studied
- Early Gastric Cancer — all drugs for Early Gastric Cancer →
Sponsor
Changhai Hospital
Who can join
Adults 18 to 75, any sex, with Early Gastric Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The pathological biopsy of gastric lesions, performed prior to endoscopic submucosal dissection (ESD), is crucial for differentiating the pathological nature of the lesions and guiding treatment decisions. However, due to the impact of biopsy sampling, the sensitivity of the pathological biopsy is not optimal. The probe - based confocal laser endomicroscopy (pCLE) technique enables the real - time display of high-resolution microscopic images of the mucosal layer (with an amplification factor of up to 1000 times) through a slender optical fiber probe that can pass through the standard endoscope's working channel. It is an optical biopsy technique and has unique value in determining the pathological nature of gastric lesions. As the Digestive Endoscopy Center of Shanghai Changhai Hospital is a national-level pCLE application demonstration center, it has prospectively collected numerous cases of pCLE examinations of gastric mucosal lesions. The main purpose of this study is to retrospectively analyze these cases and compare the sensitivity and specificity of pathological biopsy and pCLE in differentiating the pathological nature of gastric mucosal lesions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07507071
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07507071 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Changhai Hospital
- Last refreshed: 2 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07507071.
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