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NCT07088744
Comparison of the Sensitivity of pCLE and Pathological Biopsy Before ESD
trial testing Probe-based Confocal Laser Endomicroscopy in Gastric Cancer (Diagnosis) in 169 participants. Not yet recruiting.
31 August 2025
Quick facts
| Lead sponsor | Changhai Hospital |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 169 |
| Start date | 30 July 2025 |
| Primary completion | 31 August 2025 |
| Estimated completion | 15 September 2025 |
| Sites | 4 locations across China |
Drugs / interventions tested
- Probe-based Confocal Laser Endomicroscopy
- Pathological biopsy
Conditions studied
- Gastric Cancer (Diagnosis) — all drugs for Gastric Cancer (Diagnosis) →
- Gastric High-grade Intraepithelial Neoplasia — all drugs for Gastric High-grade Intraepithelial Neoplasia →
- Gastric Low-grade Intraepithelial Neoplasia — all drugs for Gastric Low-grade Intraepithelial Neoplasia →
- Gastritis — all drugs for Gastritis →
Sponsor
Changhai Hospital
Who can join
Adults 18 to 80, any sex, with Gastric Cancer (Diagnosis) or Gastric High-grade Intraepithelial Neoplasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pathological biopsy before endoscopic submucosal dissection (ESD) the gastric lesion plays an important role in differentiating the pathological nature of the lesion and guiding treatment decisions. However, due to the influence of the materials used, the sensitivity of pathological biopsy is not satisfactory. Confocal Laser Endomicroscopy (CLE) is a technology that integrates a confocal microscope into an endoscope. It enables the acquisition of high-resolution microscopic images of the mucosal layer in real-time (with a magnification of up to 1000 times), and it is an optical biopsy technique. It has unique value in the determination of the pathological nature of gastric lesions. The main purpose of this study is to compare the sensitivity of pathological biopsy and CLE in differentiating the pathological nature of gastric lesions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07088744
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Probe-based Confocal Laser Endomicroscopy
Trials testing the same drug.
- NCT07507071 — Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions · not yet recruiting
Other recruiting trials for Gastric Cancer (Diagnosis)
Currently open trials in the same condition.
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- NCT07481110 — Study of the Epidemiological, Clinical, Diagnostic, and Therapeutic Characteristics of Gastric Cancers in Algeria · recruiting
- NCT07517432 — The UGIRA International Registry for RAMIG for Gastric Cancer · recruiting
Other Changhai Hospital trials
Trials by the same sponsor.
- NCT07490002 — Neoadjuvant Therapy With Iparomlimab and Tuvonralimab, Lenvatinib and Chemotherapy in Resectable ESCC · Phase 2 · not yet recruiting
- NCT07464392 — FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute Pancreatitis · NA · recruiting
- NCT07507071 — Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions · not yet recruiting
- NCT07481591 — Capsule Endoscopy in GI Bleeding: A Retrospective Study · not yet recruiting
- NCT07439757 — AI-Powered Precision Decision-Making for Pancreatic Diseases · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07088744 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Changhai Hospital
- Last refreshed: 28 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07088744.
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