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NCT07504575: PRP
Effect of PRP in Donor Semen During Cryoprervation
trial in Sperm Cryodamage in 20 participants. Currently enrolling.
30 September 2027
Quick facts
| Lead sponsor | Instituto Valenciano de Infertilidad, IVI Alicante |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 10 February 2026 |
| Primary completion | 30 September 2027 |
| Estimated completion | 30 January 2028 |
| Sites | 1 location across Spain |
Conditions studied
- Sperm Cryodamage — all drugs for Sperm Cryodamage →
Sponsor
Instituto Valenciano de Infertilidad, IVI Alicante — full company profile →
Who can join
Adults 18 to 35, male only, with Sperm Cryodamage. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sperm cryopreservation allows the preservation of sperm biological function for long periods of time for later use in assisted reproductive techniques (ART). However, the freezing and thawing process causes structural and functional damage to sperm, leading to decreased motility and vitality, a loss of plasma membrane integrity and even DNA damage. In recent years, various strategies have been studied to protect sperm from cryodamage, including the optimization of freezing processes, the design of freezing devices, and improved freezing media. One possible measure to mitigate the cryodamage suffered by sperm is the addition of PRP, or platelet-rich plasma, to the freezing medium. In previous studies, PRP components have been shown to have positive effects on semen quality, improving motility, viability, and plasma membrane integrity after cryopreservation. In light of these positive results, this study will evaluate the possibility of incorporating PRP into sperm cryopreservation media and its potential future benefits for patients and clinical outcomes. To this end, each semen sample after a previous spermiogram will be aliquoted, and 0%, 1%, 2%, and 5% PRP will be added to the cryopreservation medium according to the sperm group to which the belong. A spermiogram will be performed after cryopreservation to assess various semen quality parameters, including sperm count, motility, morphology, vitality, and chromatin dispersion. The data must be processed through statistical analysis to obtain results that allow determining, primarily, whether there is a beneficial effect on sperm quality after sperm motility and sperm during cryopreservation with the addition of PRP.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07504575
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Related trials
Other Instituto Valenciano de Infertilidad, IVI Alicante trials
Trials by the same sponsor.
- NCT04784260 — Microbiome Influence on Seminal Quality · completed
- NCT03741699 — Recombinant LH Prior to Ovarian Stimulation in Poor Ovarian Responders (PRE-LH) · Phase 3 · completed
- NCT02527954 — Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions · terminated
- NCT02535377 — Human Sperm Markers of Cryodamage Resistance · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07504575 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Instituto Valenciano de Infertilidad, IVI Alicante
- Last refreshed: 17 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07504575.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing