Last reviewed · How we verify
NCT07478042: BEST
Guiding Catheters in Endovascular Stroke Therapy - Are Balloon Guided Catheters Superior?
NA trial testing Ballon guide catheter in Acute Ischemic Stroke Patients in 110 participants. Completed in 30 September 2025.
30 July 2025
Quick facts
| Lead sponsor | University Hospital Heidelberg |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 110 |
| Start date | 15 March 2023 |
| Primary completion | 30 July 2025 |
| Estimated completion | 30 September 2025 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Ballon guide catheter
- Guide catheter without balloon
Conditions studied
- Acute Ischemic Stroke Patients — all drugs for Acute Ischemic Stroke Patients →
- Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
- Acute Ischemic Stroke AIS — all drugs for Acute Ischemic Stroke AIS →
Sponsor
University Hospital Heidelberg
Who can join
18 and older, any sex, with Acute Ischemic Stroke Patients or Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The BEST study is an academically initiated, single-center, prospective, randomized controlled clinical trial investigating the potential advantages and disadvantages of using a guide catheter with or without a balloon in the interventional treatment of acute ischemic stroke. The study population consists of adult patients with acute ischemic stroke of the anterior circulation for whom interventional recanalization therapy via catheter is indicated following interdisciplinary consultation between the Department of Neurology and Neuroradiology at Heidelberg University Hospital. In addition to routine clinical treatment measures and data collection, patients will be interviewed by telephone after 90 days to assess their quality of life and level of independence using standardized scoring systems. All medical devices used or investigated in this study bear the CE mark (Conformité Européenne ) and will be used within their intended purpose. Study participants will not be subjected to any additional invasive or burdensome procedures beyond normal usage.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07478042
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Ischemic Stroke Patients
Currently open trials in the same condition.
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- NCT07001267 — Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received · NA · recruiting
- NCT06250608 — Evaluation of rSO2 Between Frontal Lesion Area and Normal Area of Brain by NIRSITX Using NIRS in Acute Ischemic Stroke P · NA · active not recruiting
Other University Hospital Heidelberg trials
Trials by the same sponsor.
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- NCT06913010 — DV 100 as a Framework for the Hospital Incident Command System · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07478042 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital Heidelberg
- Last refreshed: 17 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07478042.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing