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NCT07454824: e-ALIGN
e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
NA trial testing e-ALIGN Patient-Portal Deprescribing in Dementia in 100 participants. Not yet recruiting.
1 August 2026
Quick facts
| Lead sponsor | Johns Hopkins University |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 100 |
| Start date | 15 March 2026 |
| Primary completion | 1 August 2026 |
| Estimated completion | 1 December 2026 |
Drugs / interventions tested
- e-ALIGN Patient-Portal Deprescribing
Conditions studied
- Dementia — all drugs for Dementia →
- Potentially Inappropriate Medication Use — all drugs for Potentially Inappropriate Medication Use →
- Mild Cognitive Impairment (MCI) — all drugs for Mild Cognitive Impairment (MCI) →
Sponsor
Johns Hopkins University
Who can join
65 and older, any sex, with Dementia or Potentially Inappropriate Medication Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07454824
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07454824 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
- Last refreshed: 6 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07454824.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing