NCT06687655 (KETO-SLEEP 2) is a Phase 1, PHASE2 clinical trial of Ketone-IQ in Obstructive Sleep Apnea, sponsored by Johns Hopkins University.

Who is sponsoring NCT06687655?

NCT06687655 is sponsored by Johns Hopkins University.

What drugs are being tested in NCT06687655?

Interventions in NCT06687655: Ketone-IQ, Placebo.

What condition does NCT06687655 study?

NCT06687655 studies Obstructive Sleep Apnea, Sleep.

Is NCT06687655 still recruiting?

NCT06687655 is currently not yet recruiting. Last updated 10 October 2025.

Last reviewed 2025-10-10 · How we verify

NCT06687655: KETO-SLEEP 2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Exogenous Ketones on Sleep Apnea

Not yet recruiting Phase 1, PHASE2 Last updated 10 October 2025

What this trial tests

Phase 1, PHASE2 trial testing Ketone-IQ in Obstructive Sleep Apnea in 30 participants. Not yet recruiting.

Timeline

6 September 2026

Primary endpoint
6 September 2028

6 September 2028

Quick facts

Lead sponsor	Johns Hopkins University
Phase	Phase 1, PHASE2
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	30
Start date	6 September 2026
Primary completion	6 September 2028
Estimated completion	6 September 2028
Sites	1 location across United States

Drugs / interventions tested

Ketone-IQ
Placebo

Conditions studied

Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
Sleep — all drugs for Sleep →

Sponsor

Johns Hopkins University

Who can join

Adults 18 to 65, any sex, with Obstructive Sleep Apnea or Sleep. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated. The investigator's lab has shown that a low carbohydrate, high fat ketogenic diet (KD) can reduce OSA severity. Since it can be challenging to adhere to a ketogenic diet, the investigators propose that ingesting exogenous ketones can be an alternative method to improve OSA. Specifically the investigators will examine the effect of taking a commercially available product (Ketone-IQ) at bedtime on overnight ketones and sleep quality. The investigators will also examine the effect of Ketone-IQ on sleep apnea severity, compared to placebo. This project will examine the the preliminary efficacy of ingesting exogenous ketones before sleep on sleep apnea.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Obstructive Sleep Apnea

Currently open trials in the same condition.

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NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

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NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting
NCT04381897 — Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06687655 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 10 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06687655.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing