Who is sponsoring NCT07453134?

NCT07453134 is sponsored by Chulalongkorn University.

What drugs are being tested in NCT07453134?

Interventions in NCT07453134: root canal treatment and intracanal medicament, root canal treatment and intracanal medicament.

What condition does NCT07453134 study?

NCT07453134 studies Root Canal Treatment, Irrigation Activation, Oral Health Quality of Life (OHQoL) Was Assessed, Post Operative Pain After Root Canal Therapy.

Is NCT07453134 still recruiting?

NCT07453134 is currently active, enrolled. Last updated 5 March 2026.

Last reviewed 2026-03-05 · How we verify

NCT07453134

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment Outcome and Patient-reported Outcomes in Patient Undergoing Non-surgical Root Canal Treatment With Different Irrigation Protocols

Active, enrolled NA Last updated 5 March 2026

What this trial tests

NA trial testing root canal treatment and intracanal medicament in Root Canal Treatment in 90 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

7 November 2025

Primary endpoint
6 November 2027

30 April 2028

Quick facts

Lead sponsor	Chulalongkorn University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	90
Start date	7 November 2025
Primary completion	6 November 2027
Estimated completion	30 April 2028
Sites	1 location across Thailand

Drugs / interventions tested

root canal treatment and intracanal medicament — full drug profile →
root canal treatment and intracanal medicament — full drug profile →

Conditions studied

Root Canal Treatment — all drugs for Root Canal Treatment →
Irrigation Activation — all drugs for Irrigation Activation →
Oral Health Quality of Life (OHQoL) Was Assessed — all drugs for Oral Health Quality of Life (OHQoL) Was Assessed →
Post Operative Pain After Root Canal Therapy — all drugs for Post Operative Pain After Root Canal Therapy →

Sponsor

Chulalongkorn University

Who can join

Adults 18 to 80, any sex, with Root Canal Treatment or Irrigation Activation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate and compare the clinical and patient-reported outcomes of passive ultrasonic irrigation (PUI) and laser-activated irrigation (LAI) versus conventional syringe irrigation in adult patients undergoing non-surgical root canal treatment on mature permanent teeth, and to identify the key factors that influence these outcomes.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of root canal treatment and intracanal medicament

Trials testing the same drug.

NCT06804330 — Evaluation of Postoperative Pain and Antimicrobial Efficacy of Selenium Versus Calcium Hydroxide As Intracanal Medicatio · NA · not yet recruiting
NCT04319575 — Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant · Phase 2, PHASE3 · unknown

Other recruiting trials for Root Canal Treatment

Currently open trials in the same condition.

NCT07241650 — Evaluation of the Effects of Different Irrigation Solutions and Activation Methods on Postoperative Pain and Quality of · NA · active not recruiting
NCT07210177 — The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments · NA · active not recruiting

Other Chulalongkorn University trials

Trials by the same sponsor.

NCT07458659 — Clinical Study of BCMA-Targeted CAR T-Cell Injection in the Treatment of Patients With Relapsed/Refractory Multiple Myel · EARLY_PHASE1 · not yet recruiting
NCT07346118 — Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury · NA · not yet recruiting
NCT07388862 — Comparison of Treatment Outcome of Pulpotomy With Versus Without Dental Operating Microscope in Carious Mature Permanent · EARLY_PHASE1 · not yet recruiting
NCT07373977 — Comparison of Postoperative Pain After Pulpotomy Performed With Versus Without Dental Operating Microscope in Carious Ma · EARLY_PHASE1 · not yet recruiting
NCT07078929 — Clinical Trial of CMD63 Chimeric Antigen Receptor T-cell (CAR T-cell) in Children With Acute Lymphoblastic Leukemia (ALL · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07453134 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chulalongkorn University
Last refreshed: 5 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07453134.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing