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NCT06804330
Evaluation of Postoperative Pain and Antimicrobial Efficacy of Selenium Versus Calcium Hydroxide As Intracanal Medication in Mandibular First Molars with Necrotic Pulp and Symptomatic Apical Periodontitis
NA trial testing root canal treatment and intracanal medicament in Necrotic Pulp with Symptomatic Apical Periodontitis in 60 participants. Not yet recruiting.
1 June 2025
Quick facts
| Lead sponsor | Future University in Egypt |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 April 2025 |
| Primary completion | 1 June 2025 |
| Estimated completion | 1 October 2025 |
Drugs / interventions tested
- root canal treatment and intracanal medicament — full drug profile →
Conditions studied
- Necrotic Pulp with Symptomatic Apical Periodontitis — all drugs for Necrotic Pulp with Symptomatic Apical Periodontitis →
- Postoperative Dental Pain — all drugs for Postoperative Dental Pain →
- Antimicrobial Effect — all drugs for Antimicrobial Effect →
Sponsor
Future University in Egypt
Who can join
Adults 20 to 40, any sex, with Necrotic Pulp with Symptomatic Apical Periodontitis or Postoperative Dental Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The main rational behind intracanal medicament is to kill the bacteria inside the root canal and to avert reinfection. In absence of nutrients, the bacteria remains after obturation in root canal may not survive. Otherwise they may flourish \& If the root canal is not dressed properly with antiseptic medicaments between the visits, the residual bacteria may increase . Thus the use of effective intracanal medication for disinfection of root canal is necessitated . Medicament with long effect and least irritated to periradicular tissue has to be introduced to infiltrate the dentinal tubule eliminating bacteria . As the effect of intracanal medicaments is longer than irrigants, it is generally recommended to fill the root canal between appointments with intracanal medicaments. Calcium hydroxide is the most commonly recommended antimicrobial agent for interappointment medications. It serves as an effective intracanal medicament due to its alkaline pH, which inhibits bacterial growth. However, calcium hydroxide has limitations. .Recently selenium(Se) was introduced as intracanal medication .Se is a mineral essential for the formation of the amino acid selenocysteine, which is directly involved in the maintenance of the immune response. Selenium has been widely used in the medical field in the treatment of cancer, as an activator of bone metabolism, and as a stimulator of the immune system. In this study, it will show that the incorporation of Se, whether as intracanal medication alone or in conjunction with other medications, may potentiate periapical tissue repair after RCS cleaning and shaping procedures. This study consists of 60 patients divided into 3 group each group having 20 patient. Intervention 1: intracanal medication using selenium alone . Intervention 2: intracanal medication using selenium with calcium hydroxide
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06804330
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Related trials
Other trials of root canal treatment and intracanal medicament
Trials testing the same drug.
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- NCT04319575 — Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant · Phase 2, PHASE3 · unknown
Other Future University in Egypt trials
Trials by the same sponsor.
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- NCT06950762 — Aesthetic Performance of Two Injectable Resin Composites in Class V Cavities: A Randomized Clinical Trial · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06804330 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Future University in Egypt
- Last refreshed: 19 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06804330.
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