NCT07433426 (TrtNDSD) is a Phase 2 clinical trial of Azithromycin in Diarrhea Infectious, sponsored by Johns Hopkins Bloomberg School of Public Health.

Who is sponsoring NCT07433426?

NCT07433426 is sponsored by Johns Hopkins Bloomberg School of Public Health.

What drugs are being tested in NCT07433426?

Interventions in NCT07433426: Azithromycin, Placebo.

What condition does NCT07433426 study?

NCT07433426 studies Diarrhea Infectious, Shigella, Growth & Development.

Is NCT07433426 still recruiting?

NCT07433426 is currently recruiting now. Last updated 27 March 2026.

Last reviewed 2026-03-27 · How we verify

NCT07433426: TrtNDSD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of Shigellosis and Recommended Treatment in Children

Recruiting now Phase 2 Last updated 27 March 2026

What this trial tests

Phase 2 trial testing Azithromycin in Diarrhea Infectious in 700 participants. Currently enrolling.

Timeline

18 March 2026

Primary endpoint
1 August 2029

1 August 2030

Quick facts

Lead sponsor	Johns Hopkins Bloomberg School of Public Health
Phase	Phase 2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	700
Start date	18 March 2026
Primary completion	1 August 2029
Estimated completion	1 August 2030
Sites	4 locations across Bangladesh, Zambia

Drugs / interventions tested

Azithromycin (azithromycin) — full drug profile →
Placebo

Conditions studied

Diarrhea Infectious — all drugs for Diarrhea Infectious →
Shigella — all drugs for Shigella →
Growth & Development — all drugs for Growth & Development →

Sponsor

Johns Hopkins Bloomberg School of Public Health

Who can join

Adults 6 Months to 59 Months, any sex, with Diarrhea Infectious or Shigella. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Time to cessation of diarrhea (TCD)
Time frame: From the time of the administration of Azithromycin or placebo until cessation of the diarrhea episode (approximately up to a month)
Diarrhea will be defined as 3 or more liquid or loose stool during a 24 hours period (not calendar day). Two diarrhea episodes will be separated by three diarrhea free days in between. Time to cessation of diarrhea (TCD) will be expressed in hours.
Change in weight for age Z score (WAZ)
Time frame: From enrollment to the 90-day follow up
The change in weight for age Z scores from enrollment to the 90-day follow-up

Sponsor's own description

The purpose of this study is to evaluate whether antibiotic treatment of non-dysentery Shigella associated watery diarrhea (NDSD) cases improves clinical outcomes and growth in children. Children with NDSD seeking care for diarrhea at the study hospitals in Bangladesh and Zambia will be enrolled and randomized to receive Azithromycin or placebo (a look-alike substance that contains no drug). Enrolled children will be followed for three months with household visits. The investigators will determine whether antibiotic treatment of NDSD reduces the duration of diarrhea and time to microbiological cure (shedding of Shigella in stool), and whether it improves growth in children compared with the placebo group.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Azithromycin

Trials testing the same drug.

NCT07306234 — Doxycycline vs. Macrolide for MRMP (DOMINO) · Phase 4 · not yet recruiting
NCT06461429 — PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] · NA · not yet recruiting
NCT07164131 — Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lacta · Phase 4 · recruiting
NCT07052942 — Individualizing Treatment for Asthma in Primary Care (Full Study) · Phase 4 · recruiting
NCT07213765 — Short-term Antibiotic Therapy in Mycobacterium Avium Complex Pulmonary Disease · Phase 4 · recruiting

Other recruiting trials for Diarrhea Infectious

Currently open trials in the same condition.

NCT07195006 — Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories · recruiting
NCT06498817 — Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7) · NA · recruiting
NCT05166850 — Preventative Intervention for Cholera for 7 Days · NA · recruiting

Other Johns Hopkins Bloomberg School of Public Health trials

Trials by the same sponsor.

NCT07458230 — Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation: · Phase 3 · not yet recruiting
NCT07227558 — Improving Information Sharing Between Family Caregivers and Home Care Aides · NA · recruiting
NCT07536126 — Testing Non-Nutrition Menu Labels on Food Selections · NA · not yet recruiting
NCT06426004 — Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland · NA · not yet recruiting
NCT07344142 — Improving Digital Wellbeing in Saudi Adolescents · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07433426 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins Bloomberg School of Public Health
Last refreshed: 27 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07433426.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing