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Zithromax (azithromycin)
Macrolide antibiotic that binds the 50S ribosomal subunit, inhibiting bacterial protein synthesis with an exceptionally long tissue half-life.
Azithromycin (Zithromax/Z-Pack) is one of the world\
At a glance
| Generic name | azithromycin |
|---|---|
| Also known as | Zithromax, Z-Pack, Zmax |
| Sponsor | Pfizer Inc. |
| Drug class | Macrolide antibiotic (azalide) |
| Target | Canalicular multispecific organic anion transporter 1, Taste receptor type 2 member 4, Motilin receptor |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
| First approval | 1991-11-01 (United States) |
| Annual revenue | 399 |
Mechanism of action
Azithromycin is an azalide antibiotic (structurally related to macrolides) with a uniquely long tissue half-life of 68 hours, allowing short-course therapy (the famous \
Approved indications
- Acute bacterial bronchitis
- Acute bacterial sinusitis
- Acute exacerbation of chronic bronchitis
- Acute gonococcal cervicitis
- Acute gonococcal urethritis
- Bacterial blepharitis
- Bacterial conjunctivitis
- Bacterial hordeolum
- Bacterial pneumonia
- Chancroid
- Chlamydia Cervicitis
- Chlamydial pelvic inflammatory disease
- Chlamydial pneumonia
- Dacryocystitis
- Haemophilus Influenzae Acute Otitis Media
- Haemophilus influenzae pneumonia
- Infection due to Staphylococcus aureus
- Infective otitis media
- Legionella Pneumophila Pneumonia
- Moraxella Catarrhalis Acute Otitis Media
Common side effects
- Nausea
- Diarrhea
- Abdominal pain
- Vomiting
- Pain at the injection site
- Local inflammation
- Diarrhea
- Nausea
- Vaginitis
- Abdominal pain
- Anorexia
- Rash and pruritus
Drug interactions
- Nelfinavir
- Warfarin
- Digoxin
- Colchicine
- Phenytoin
Key clinical trials
- Improving Care Through Azithromycin Research for Infants in Africa (PHASE3)
- A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction (PHASE3)
- Azithromycin Reduction to Reach Elimination of Trachoma (PHASE4)
- Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis (PHASE3)
- Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial (PHASE2)
- A Study of Standard Drugs for Mycobacterium Avium Complex (PHASE2)
- An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM (PHASE3)
- Antibiotic Treatment of Recurrent Episodes of Asthma in Children (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
| SEC EDGAR | Revenue + earnings |