Last reviewed · How we verify
NCT07431892: PEARL
Pain Evaluation Across Robotic and Laparoscopic Surgery for Colorectal Procedures
trial in Minimally Invasive Surgical Procedures in 80 participants. Currently enrolling.
28 February 2026
Quick facts
| Lead sponsor | Hospital Central de la Defensa Gómez Ulla |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 1 September 2025 |
| Primary completion | 28 February 2026 |
| Estimated completion | 1 September 2028 |
| Sites | 1 location across Spain |
Conditions studied
- Minimally Invasive Surgical Procedures — all drugs for Minimally Invasive Surgical Procedures →
- Colon Cancer Patients — all drugs for Colon Cancer Patients →
Sponsor
Hospital Central de la Defensa Gómez Ulla
Who can join
18 and older, any sex, with Minimally Invasive Surgical Procedures or Colon Cancer Patients. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Minimally invasive surgery for colorectal conditions, such as laparoscopic or robotic surgery, has been shown to offer benefits over traditional open surgery. These benefits include less pain after surgery, shorter hospital stays, and fewer complications. This study aims to compare two types of minimally invasive surgery-laparoscopic and robotic surgery-to determine which approach results in less postoperative pain for patients undergoing colon or rectal surgery. The central hypothesis is that robotic surgery, due to its higher precision and reduced tissue trauma, will lead to lower pain levels after surgery. The study will enroll adult patients scheduled for elective colorectal surgery at the Hospital General Universitario Gregorio Marañón in Madrid. Participants will undergo either laparoscopic or robotic surgery based on clinical availability and surgical planning, as long as they meet all inclusion criteria under the hospital's enhanced recovery protocol (RICA program). Researchers will assess patients' pain levels at different time points after surgery (immediately after recovery, at 24, 48, and 72 hours, and at discharge) using validated pain scales. The use of pain medications, hospital stay duration, complication rates, and quality of life up to 12 months after surgery will also be measured. All patient data will be collected anonymously using a secure electronic system (REDCap). The study will last approximately 2 years and include about 80 patients (40 in each group). The results could help surgeons and hospitals choose the most effective surgical approach to reduce postoperative pain and improve patient recovery in colorectal surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07431892
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Hospital Central de la Defensa Gómez Ulla trials
Trials by the same sponsor.
- NCT04311385 — Management and Evolution of Acute Diverticulitis With Pericolic Free Gas · completed
- NCT04194151 — Impact of Propofol Reduction in Anesthesia Induction · Phase 4 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07431892 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Central de la Defensa Gómez Ulla
- Last refreshed: 25 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07431892.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing