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NCT07427121: REHAB-MV
Rehab and Mechanical Ventilation
NA trial testing Spinal cord stimulation in Inspiratory Strength Training (IST) in 16 participants. Not yet recruiting.
31 March 2027
Quick facts
| Lead sponsor | University of Florida |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 16 |
| Start date | 10 March 2026 |
| Primary completion | 31 March 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Spinal cord stimulation
- Inspiratory Strength Training
- Sham Stimulation
Conditions studied
- Inspiratory Strength Training (IST) — all drugs for Inspiratory Strength Training (IST) →
- Transcutaneous Spinal Stimulation — all drugs for Transcutaneous Spinal Stimulation →
- Sham Spinal Stimulation — all drugs for Sham Spinal Stimulation →
Sponsor
University of Florida
Who can join
Adults 25 to 80, any sex, with Inspiratory Strength Training (IST) or Transcutaneous Spinal Stimulation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07427121
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07427121 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Florida
- Last refreshed: 27 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07427121.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing