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NCT07426081
Comparison of Dexmedetomidine and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Phase 3 trial testing Dexamedomedine in Postoperative Nausea and Vomiting in 68 participants. Completed in 15 November 2025.
15 November 2025
Quick facts
| Lead sponsor | Patel Hospital, Pakistan |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | other |
| Enrollment | 68 |
| Start date | 1 June 2025 |
| Primary completion | 15 November 2025 |
| Estimated completion | 15 November 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Dexamedomedine — full drug profile →
- Dexamethasone (dexamethasone) — full drug profile →
Conditions studied
- Postoperative Nausea and Vomiting — all drugs for Postoperative Nausea and Vomiting →
Sponsor
Patel Hospital, Pakistan
Who can join
Adults 18 to 60, any sex, with Postoperative Nausea and Vomiting. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative nausea and vomiting (PONV) remains a common and distressing complication after laparoscopic cholecystectomy despite advances in anesthesia. Both dexmedetomidine and dexamethasone have shown antiemetic properties, but their comparative effectiveness is still debated. To compare the efficacy of dexmedetomidine and dexamethasone in preventing PONV in patients undergoing laparoscopic cholecystectomy. This double-blind randomized controlled trial included 68 ASA I-II patients scheduled for elective laparoscopic cholecystectomy. Patients were randomly allocated to receive either intravenous dexmedetomidine (1 μg/kg) or dexamethasone (8 mg) after induction of anesthesia. PONV was assessed using a standardized scoring system on arrival in the PACU and at 4, 12, and 24 hours postoperatively. Ondansetron was administered as rescue antiemetic when required. This study aims to determine the more effective prophylactic agent for PONV, with the goal of improving postoperative comfort and quality of care in patients undergoing laparoscopic surgery in the local population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07426081
- Europe PMC full search
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Related trials
Other trials of Dexamedomedine
Trials testing the same drug.
- NCT07380139 — Dexamethasone vs Dexmedetomidine in Sphenopalatine Ganglion Block for Rhinoplasty Pain · Phase 1 · enrolling by invitation
- NCT07199595 — Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy · NA · not yet recruiting
Other recruiting trials for Postoperative Nausea and Vomiting
Currently open trials in the same condition.
- NCT07336160 — ERAS-Based Preoperative Nutrition and Fasting in Total Knee Arthroplasty · NA · recruiting
- NCT07242209 — Sugammadex and Menstrual Cycle in Postoperative Nausea and Vomiting · recruiting
- NCT07244575 — Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General · recruiting
- NCT06632184 — Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy · Phase 4 · active not recruiting
- NCT07271147 — Effects of taVNS Combined With Dexmedetomidine on POVN · NA · recruiting
Other Patel Hospital, Pakistan trials
Trials by the same sponsor.
- NCT07300137 — Comparison of Amniotic Membrane Dressing and Aquacel®Ag in Second-degree Burns · NA · enrolling by invitation
- NCT07469410 — Comparison of Postoperative Analgesia in Erector Spinae Plane Block (ESPB) v/s Subcostal Transversus Abdominal Plane Blo · Phase 3 · completed
- NCT07002749 — ROLE OF PROPHYLACTIC TRANEXAMIC ACID IN PREVENTION OF POST-PARTUM HEMORRHAGE IN ELLSCS · Phase 1 · not yet recruiting
- NCT06949189 — Nail Bed Repair With or Without Nail Bed Coverage · NA · completed
- NCT07098780 — Role of Tranexamic Acid in Reducing Hemorrhagic Events in Bariatric Surgery · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07426081 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Patel Hospital, Pakistan
- Last refreshed: 23 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07426081.
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