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NCT07421817: PONV-DEX-GYN
Dexamethasone for Prevention of Postoperative Vomiting After Laparoscopic Gynecologic Surgery
NA trial testing Dexamethasone in Postoperative Nausea and Vomiting (PONV) in 120 participants. Completed in 31 March 2018.
31 March 2018
Quick facts
| Lead sponsor | Rawalpindi Medical College |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 120 |
| Start date | 1 October 2017 |
| Primary completion | 31 March 2018 |
| Estimated completion | 31 March 2018 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Dexamethasone (dexamethasone) — full drug profile →
- Placebo (Normal Saline)
Conditions studied
- Postoperative Nausea and Vomiting (PONV) — all drugs for Postoperative Nausea and Vomiting (PONV) →
Sponsor
Rawalpindi Medical College
Who can join
Adults 15 to 65, female only, with Postoperative Nausea and Vomiting (PONV). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative nausea and vomiting (PONV) are common and distressing complications following laparoscopic gynecologic surgery. This randomized controlled trial evaluated whether a single preoperative intravenous dose of dexamethasone reduces postoperative vomiting compared with placebo and explored patient-related risk factors associated with PONV. Women undergoing elective laparoscopic gynecologic surgery were randomly assigned to receive dexamethasone (5 mg IV) or placebo at induction of anesthesia. The primary outcome was the incidence of postoperative vomiting within 24 hours, with secondary outcomes including nausea severity, rescue antiemetic use, and postoperative recovery parameters.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07421817
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Postoperative Nausea and Vomiting (PONV)
Currently open trials in the same condition.
- NCT07440667 — Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section · NA · recruiting
- NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
- NCT07534956 — The Effect of Paedfusor TCI, Eleveld TCI, and Sevoflurane Anesthesia on Postoperative Awakening Agitation in Pediatric P · NA · recruiting
- NCT07148063 — Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy · recruiting
- NCT07201883 — Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients · Phase 1 · active not recruiting
Other Rawalpindi Medical College trials
Trials by the same sponsor.
- NCT07420127 — Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect · Phase 4 · recruiting
- NCT07409688 — Pain Relief Following Laparoscopic Cholecystectomy While Comparing Intra Abdominal Versus Sub Cutaneous Local Anesthetic · Phase 4 · recruiting
- NCT07092943 — Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Sur · NA · recruiting
- NCT07088146 — Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients · Phase 4 · recruiting
- NCT07078786 — Effect of Pre-delivery Dexamethasone in Comparison With Betamethasone on Fetal Heart Trace · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07421817 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rawalpindi Medical College
- Last refreshed: 20 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07421817.
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