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NCT07201883
Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients
Phase 1 trial testing Ondansetron (Zofran) in Postoperative Nausea and Vomiting (PONV) in 90 participants. Participants enrolled and being followed up; not accepting new ones.
28 February 2026
Quick facts
| Lead sponsor | Makassed General Hospital |
|---|---|
| Phase | Phase 1 |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 22 August 2025 |
| Primary completion | 28 February 2026 |
| Estimated completion | 28 February 2026 |
| Sites | 1 location across Lebanon |
Drugs / interventions tested
- Ondansetron (Zofran) — full drug profile →
- chewing gum — full drug profile →
- Ondansetron + Chewing gum
Conditions studied
- Postoperative Nausea and Vomiting (PONV) — all drugs for Postoperative Nausea and Vomiting (PONV) →
Sponsor
Makassed General Hospital
Who can join
18 and older, female only, with Postoperative Nausea and Vomiting (PONV). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The proposed randomized clinical trial aims to test and compare the efficacy of chewing gum vs. Intravenous antiemetic ondansetron as rescue treatment for post-operative nausea and vomiting (PONV) among Lebanese female patients undergoing laparoscopic surgery in the post-operative anesthesia care unit (PACU).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07201883
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ondansetron (Zofran)
Trials testing the same drug.
- NCT06886230 — Ondansetron vs. Dexamethasone for Postoperative Nausea · Phase 4 · completed
- NCT06727201 — Role of Ondansetron in Spinal Anaesthesia Induced Hypotension · Phase 2, PHASE3 · not yet recruiting
Other recruiting trials for Postoperative Nausea and Vomiting (PONV)
Currently open trials in the same condition.
- NCT07440667 — Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section · NA · recruiting
- NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
- NCT07534956 — The Effect of Paedfusor TCI, Eleveld TCI, and Sevoflurane Anesthesia on Postoperative Awakening Agitation in Pediatric P · NA · recruiting
- NCT07148063 — Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy · recruiting
- NCT07026162 — Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery · Phase 4 · recruiting
Other Makassed General Hospital trials
Trials by the same sponsor.
- NCT07182110 — Dexamethasone-Enhanced TAP Block in Lapchole · Phase 1 · active not recruiting
- NCT07049835 — Ilioinguinal Nerve Block With Local Anesthetic vs. Placebo in Inguinal Hernia Repair Under Spinal Anesthesia · Phase 1 · active not recruiting
- NCT06963229 — Spinal Anesthesia Vs. Neve Block in Risk of Cognitive Decline · NA · active not recruiting
- NCT06917898 — Fentanyl Versus Midazolam as an Adjunct to Spinal Anesthesia · Phase 1 · active not recruiting
- NCT05161611 — Effect of Oral Zinc Sulfate on Jaundice in Neonates Admitted to Neonatal Intensive Care Unit · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07201883 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Makassed General Hospital
- Last refreshed: 1 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07201883.
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