NCT07414745 is a NA clinical trial of MDT-0123 in Disc Degeneration, sponsored by Medtronic Spinal and Biologics.

Who is sponsoring NCT07414745?

NCT07414745 is sponsored by Medtronic Spinal and Biologics.

What drugs are being tested in NCT07414745?

Interventions in NCT07414745: MDT-0123, ICBG.

What condition does NCT07414745 study?

NCT07414745 studies Disc Degeneration, Spinal Deformity.

Is NCT07414745 still recruiting?

NCT07414745 is currently not yet recruiting. Last updated 17 February 2026.

Last reviewed 2026-02-17 · How we verify

NCT07414745

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

MDT-0123 Japan Study

Not yet recruiting NA Last updated 17 February 2026

What this trial tests

NA trial testing MDT-0123 in Disc Degeneration in 140 participants. Not yet recruiting.

Timeline

28 February 2026

Primary endpoint
31 March 2028

31 March 2028

Quick facts

Lead sponsor	Medtronic Spinal and Biologics
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	140
Start date	28 February 2026
Primary completion	31 March 2028
Estimated completion	31 March 2028
Sites	13 locations across Japan

Drugs / interventions tested

MDT-0123
ICBG

Conditions studied

Disc Degeneration — all drugs for Disc Degeneration →
Spinal Deformity — all drugs for Spinal Deformity →

Sponsor

Medtronic Spinal and Biologics — full company profile →

Who can join

Adults 18 to 80, any sex, with Disc Degeneration or Spinal Deformity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this clinical trial is to compare the efficacy and safety of this investigational device with autologous iliac bone graft (ICBG) in patients who are deemed to require bone fusion through spinal fixation at two levels (ALIF or OLIF) due to disc degeneration or spinal deformity in the lumbosacral spine (L2-S1) for intervertebral support and correction with the aim of stabilizing the spine.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Disc Degeneration

Currently open trials in the same condition.

NCT06367855 — Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF · Phase 4 · recruiting
NCT05412277 — VIA Disc Nucleus Pulposus Older Patients Pilot · NA · active not recruiting
NCT05201287 — VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs · NA · active not recruiting

Other Medtronic Spinal and Biologics trials

Trials by the same sponsor.

NCT05299762 — A Post Market Surveillance on INFUSE Bone Graft · recruiting
NCT04929678 — Study of the Braive Growth Modulation System for Progressive Pediatric Scoliosis · NA · terminated
NCT03775694 — Diffusion MRI-1 Imaging Database · completed
NCT03797144 — Fenestrated Screw Study · NA · terminated
NCT03730207 — Xpede Clinical Study · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07414745 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medtronic Spinal and Biologics
Last refreshed: 17 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07414745.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing