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NCT07394725
Unlocking New Avenues: Azithromycin Vs Erythromycin in Pre-term, Pre-mature Rupture of Membrane Management
Phase 1 trial testing Erythromycin in Pre-term Premature Rupture of Membranes in 250 participants. Completed in 31 March 2025.
31 March 2025
Quick facts
| Lead sponsor | District Headquarters Teaching Hospital Sahiwal |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 250 |
| Start date | 1 April 2024 |
| Primary completion | 31 March 2025 |
| Estimated completion | 31 March 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Erythromycin (erythromycin) — full drug profile →
- Azithromycin (azithromycin) — full drug profile →
Conditions studied
- Pre-term Premature Rupture of Membranes — all drugs for Pre-term Premature Rupture of Membranes →
Sponsor
District Headquarters Teaching Hospital Sahiwal
Who can join
Adults 18 to 40, female only, with Pre-term Premature Rupture of Membranes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial at Sahiwal Teaching Hospital (April 2024-March 2025) compared azithromycin and erythromycin for managing preterm premature rupture of membranes (PPROM) in 250 women (28-33+6 weeks gestation). Participants received either azithromycin 500 mg once daily or erythromycin 250 mg every six hours for seven days.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07394725
- Europe PMC full search
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Related trials
Other trials of Erythromycin
Trials testing the same drug.
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- NCT06948747 — A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of E · Phase 1 · completed
- NCT06574204 — Clinical Observations of Pain and Pruritus Induced by Exposure to Allergic Contact Dermatitis Caused by Macrolides · not yet recruiting
- NCT06395610 — Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers · Phase 1 · completed
- NCT06273891 — Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of Membranes · Phase 3 · recruiting
Other District Headquarters Teaching Hospital Sahiwal trials
Trials by the same sponsor.
- NCT06975488 — Effectiveness of LASER in Treatment of Ureteric Stones. · NA · completed
- NCT06707051 — Effect of Tranexamic Acid and Calcium Dobesilate for Bleeding of Endometrial Origin · Phase 2, PHASE3 · completed
- NCT04958564 — Comparison of Interlock Nailing Versus Dynamic Compression Plating in Transverse Fractures of Tibia · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07394725 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by District Headquarters Teaching Hospital Sahiwal
- Last refreshed: 6 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07394725.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing