Last reviewed · How we verify
NCT07394010
Role of Cardiopulmonary Exercise Testing in People With Heart Failure With Preserved Ejection Fraction
trial testing Cardiopulmonary Exercise Test in Heart Failure With Preserved Ejection Fraction (HFPEF) in 40 participants. Completed in 10 June 2025.
10 June 2025
Quick facts
| Lead sponsor | University of Ulster |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 1 June 2023 |
| Primary completion | 10 June 2025 |
| Estimated completion | 10 June 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Cardiopulmonary Exercise Test
Conditions studied
- Heart Failure With Preserved Ejection Fraction (HFPEF) — all drugs for Heart Failure With Preserved Ejection Fraction (HFPEF) →
Sponsor
University of Ulster
Who can join
Adults 18 to 80, any sex, with Heart Failure With Preserved Ejection Fraction (HFPEF). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Heart failure affects 1-2% of the adult population. Up to half of these patients have apparently normal heart pumping function, known as heart failure with preserved ejection fraction (HFpEF). Because HFpEF typically occurs in elderly patients with multiple comorbidities, many different mechanisms could drive symptoms and life expectancy, and it has been difficult to find effective treatments that work for all. Symptoms of HFpEF occur during exertion. The current scoring system for the diagnosis of HFpEF is not able to identify the majority of people and the majority of people remain in the zone of diagnostic uncertainty; there is no definite follow-up strategy, thus people do not receive appropriate treatment. Also, the medications, prehabilitation, and rehabilitation services are not personalised. To cater to these gaps in clinical practice, this study was set up to use Cardiopulmonary exercise testing (CPET) to understand the complexity of this disease. The investigators plan to recruit patients with clinical suspicion of HFpEF, referred to the Cardiology Department at Ulster Hospital, Belfast, UK. After screening the medical records of patients based on the inclusion and exclusion criteria, the investigators recruited 40 patients to undergo a cardiopulmonary exercise test. CPET parameters related to the heart, lungs and muscles were recorded in real time, as the patient exercised on the bike to maximal effort. The CPET data were then analysed to answer the above-mentioned clinical gaps. To disseminate the findings, the investigators plan to present the results at scientific, clinical, and patient group meetings and publish the findings in medical journals, to reach a wide array of healthcare professionals and policymakers.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07394010
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cardiopulmonary Exercise Test
Trials testing the same drug.
- NCT06325280 — Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease · recruiting
- NCT06236490 — Validation of Blood Oxygen Level Test in Well-trained Athletes · completed
- NCT05036252 — Study of Cardiopulmonary Exercise Testing in Women Who Have HER2-Positive Breast Cancer With Mild Cardiotoxicity · active not recruiting
- NCT04833010 — Effects of Face Masks During Exercise · NA · completed
- NCT04342351 — Early Treatment of ARNI on Myocardial Remodeling and Progress · Phase 4 · unknown
Other recruiting trials for Heart Failure With Preserved Ejection Fraction (HFPEF)
Currently open trials in the same condition.
- NCT07185100 — Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using · recruiting
- NCT06905405 — The Use of Advanced Imaging in HFpEF · recruiting
- NCT06909682 — AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices · recruiting
- NCT07053475 — IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches · Phase 4 · recruiting
- NCT06862908 — A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity · Phase 2 · recruiting
Other University of Ulster trials
Trials by the same sponsor.
- NCT07253155 — Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity. · NA · enrolling by invitation
- NCT06667505 — To Test an e-Health Educational Intervention Patients With an ICD · NA · recruiting
- NCT06945003 — Study of Exercise Capacity and Physical Activity in Children With Congenital Heart Disease · NA · not yet recruiting
- NCT06914804 — Stomasense: A New Route to the Proactive Detection and Management of Leaks Within Ostomy Pouches · NA · enrolling by invitation
- NCT06921811 — Bioavailability From Chickpea Meals in Ileostomists? · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07394010 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Ulster
- Last refreshed: 6 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07394010.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing