NCT07391124: IPR

In Vivo Pulp Thermal Changes During Different Slenderization Techniques

Active, enrolled NA Last updated 17 February 2026

What this trial tests

NA trial testing High-Speed Air-Driven Drill (Airotor and Bur) in Irreversible Pulpitis in 30 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

29 September 2024

Primary endpoint
29 October 2026

29 October 2026

Quick facts

Lead sponsor	Armed Forces Institute of Dentistry, Pakistan
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	30
Start date	29 September 2024
Primary completion	29 October 2026
Estimated completion	29 October 2026
Sites	1 location across Pakistan

Drugs / interventions tested

• High-Speed Air-Driven Drill (Airotor and Bur)
• Orthodontic IPR Kit (Oscillating System)

Conditions studied

• Irreversible Pulpitis — all drugs for Irreversible Pulpitis →
• Reversible Pulpitis — all drugs for Reversible Pulpitis →
• Thermal Injury — all drugs for Thermal Injury →
• Pulp Hyperemia — all drugs for Pulp Hyperemia →

Sponsor

Armed Forces Institute of Dentistry, Pakistan

Who can join

Adults 12 to 25, any sex, with Irreversible Pulpitis or Reversible Pulpitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this study is to learn about the temperature rise inside the living part of a tooth (the pulp) during different ways of removing a small amount of enamel (the hard outer layer of the tooth), a procedure called Interproximal Enamel Reduction (IPR).

The goal of this study is to learn about the temperature rise inside the living part of a tooth (the pulp) during different ways of removing a small amount of enamel (the hard outer layer of the tooth), a procedure called Interproximal Enamel Reduction (IPR).

The main question it aims to answer is:

Which IPR technique causes the highest temperature rise in the live tooth pulp?

This study is important because, until now, no research has measured these temperature changes in the live pulp of teeth inside a person's mouth (in vivo) that includes both premolars and front teeth (incisors). The original studies only used premolars, and the results might be different for front teeth due to the difference in enamel thickness.

Researchers will use 20 premolar teeth and 20 incisors that will be scheduled for extraction as part of orthodontic treatment. The teeth will be divided into two groups based on the IPR method used:

Group 1: IPR using a high-speed air-driven drill (airotor) and bur. Group 2: IPR using an orthodontic IPR kit (an oscillating system).

Participants will:

Receive local anesthesia to numb the tooth. Have the baseline temperature of the pulp recorded using temperature sensor on either side of the teeth.

Have the temperature changes in the pulp recorded using temperature sensor while IPR is performed on the sides of the tooth.

Have the tooth extracted afterward (as part of original orthodontic plan)

The key findings may provide information of the IPR method that cause a temperature rise high enough to harm the pulp. A rise beyond 5.5∘C may cause pulp damage.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.