NCT07390357

Effect of Photobiomodulation on Orthodontic Tooth Movement

Completed NA Last updated 10 February 2026

What this trial tests

NA trial testing 635-nm photobiomodulation in Class II Malocclusion in 18 participants. Completed in 27 July 2022.

Timeline

5 January 2021

Primary endpoint
10 October 2021

27 July 2022

Quick facts

Lead sponsor	Wroclaw Medical University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	18
Start date	5 January 2021
Primary completion	10 October 2021
Estimated completion	27 July 2022
Sites	1 location across Poland

Drugs / interventions tested

• 635-nm photobiomodulation
• Sham photobiomodulation

Conditions studied

• Class II Malocclusion — all drugs for Class II Malocclusion →
• Orthodontic Tooth Movement — all drugs for Orthodontic Tooth Movement →

Sponsor

Wroclaw Medical University

Who can join

18 and older, any sex, with Class II Malocclusion or Orthodontic Tooth Movement. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluated whether photobiomodulation (PBM), a form of low-level light therapy, can accelerate orthodontic tooth movement during canine distalization in adult patients undergoing fixed orthodontic treatment.

Eighteen adult patients requiring extraction of maxillary first premolars as part of orthodontic treatment for Class II malocclusion were enrolled. The study used a randomized, controlled, split-mouth design, in which one side of the maxilla was randomly assigned to receive PBM therapy, while the contralateral side served as an untreated control. This design allowed each participant to act as their own control.

All patients underwent standard orthodontic treatment with fixed appliances and absolute anchorage provided by orthodontic mini-implants. Canine distalization was performed using nickel-titanium closed-coil springs delivering comparable orthodontic forces on both sides. Photobiomodulation was applied on the experimental side using a 635-nm diode laser according to a predefined schedule over a 45-day period, while no laser treatment was applied on the control side.

The primary outcome was the amount of canine tooth movement, measured in millimeters at baseline and at follow-up visits using a calibrated orthodontic caliper. Tooth movement on the laser-treated side was compared with movement on the control side over time.

The purpose of this study was to determine whether photobiomodulation could safely and effectively increase the rate of orthodontic tooth movement without additional surgical intervention or pharmacological treatment.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.