NCT07340242 is a NA clinical trial of MARA appliance in Class II Malocclusion, sponsored by Mansoura University.

Who is sponsoring NCT07340242?

NCT07340242 is sponsored by Mansoura University.

What drugs are being tested in NCT07340242?

Interventions in NCT07340242: MARA appliance, fixed twin block.

What condition does NCT07340242 study?

NCT07340242 studies Class II Malocclusion, Mandibular Deficiency.

Is NCT07340242 still recruiting?

NCT07340242 is currently recruiting now. Last updated 14 January 2026.

Last reviewed 2026-01-14 · How we verify

NCT07340242

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dentoskeletal Effects of 3D-Printed Fixed Twin Block Versus MARA Appliances in Management of Skeletal Class II

Recruiting now NA Last updated 14 January 2026

What this trial tests

NA trial testing MARA appliance in Class II Malocclusion in 60 participants. Currently enrolling.

Timeline

27 April 2025

Primary endpoint
15 October 2026

27 April 2027

Quick facts

Lead sponsor	Mansoura University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	60
Start date	27 April 2025
Primary completion	15 October 2026
Estimated completion	27 April 2027
Sites	1 location across Egypt

Drugs / interventions tested

MARA appliance
fixed twin block

Conditions studied

Class II Malocclusion — all drugs for Class II Malocclusion →
Mandibular Deficiency — all drugs for Mandibular Deficiency →

Sponsor

Mansoura University

Who can join

Adults 9 to 14, any sex, with Class II Malocclusion or Mandibular Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Objective: to evaluate the dentoskeletal effects of CAD/CAM 3D-Printed fixed twin block versus MARA appliances in the management of skeletal class II due to Mandibular Deficiency in Preadolescence Class II malocclusion is considered one of the most commonly observed problems among orthodontic patients, representing around one-third of the patients seeking orthodontic treatment reflecting a significant economic impact. Various removable and fixed functional appliances are commonly used to stimulate mandibular growth. Fixed Twin-block appliance has advantages compared with removable Twin-block and Herbst appliances. The mandibular anterior repositioning appliance is referred to as M.A.R.A. appliance. Materials and method: The study design is a randomized controlled trial in which the control group and intervention groups will be assessed as parallel groups with a 1:1:1 allocation ratio. Sixty subjects will be enrolled in this research. They will be divided equally into three groups: untreated control, MARA group and Twin block group

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Class II Malocclusion

Currently open trials in the same condition.

NCT05684510 — Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy · NA · recruiting
NCT07361172 — Ready-made vs. Custom-made Carriere Motion Appliance · NA · recruiting
NCT06511219 — Maxillary Segmental Distalization Using Digitally Printed Appliances · NA · recruiting
NCT06651944 — Invisalign® System with Mandibular Advancement · NA · recruiting
NCT06308640 — Evaluation of Maxillary Molar Distalization With Two Bone Supported Protocols Using Cone Beam Computed Tomography · NA · active not recruiting

Other Mansoura University trials

Trials by the same sponsor.

NCT05785377 — Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia · NA · not yet recruiting
NCT07509567 — Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite Treatment · NA · not yet recruiting
NCT07393178 — Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones · NA · not yet recruiting
NCT07436182 — Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. · Phase 4 · not yet recruiting
NCT07534943 — Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Period · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07340242 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mansoura University
Last refreshed: 14 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07340242.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing